ArticleNeural plasticity2019
The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment.
Article in Neural plasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Review
- Targeting mechanisms in cognitive training for neurodegenerative diseases.Neural regeneration research · 2021Article
- White-Matter Hyperintensity Load and Differences in Resting-State Network Connectivity Based on Mild Cognitive Impairment Subtype.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cerebrovascular burden is a common pathology in mild cognitive impairment (MCI) and Alzheimer's disease (AD), with an additive impact on cognitive functioning. Despite being proposed as a potential moderator of cholinesterase inhibiting drug therapy, there is a paucity of evidence investigating the impact of cerebrovascular pathology on responsiveness to cognitive interventions. Method: The current study uses neuropsychological, neurostructural, and functional connectivity indices to characterise response to a cognitive stimulation paradigm in 25 healthy ageing and 22 MCI participants, to examine the hypothesised detrimental effects of concurrent vascular pathology. Results: In both healthy ageing and MCI, increased levels of vascular pathology limited the potential for a neuroplastic response to cognitive stimulation. In healthy ageing, participants with lower levels of vascular burden had greater functional connectivity response in the target posterior default mode network. Those with low levels of vascular pathology in the MCI cohort had increased functional connectivity of the right insula and claustrum within the salience network. Burden did not, however, predict cognitive or neuroanatomical changes. Conclusions: The current research evidences the modulatory effect of cerebrovascular pathology in interventions aimed at re-establishing network connectivity to prevent cognitive deterioration and delay the transition to the dementia stage of AD. Examination of co-occurring vascular pathology may improve precision in targeting treatment to MCI candidates who may respond optimally to such cognitive interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.