Evidence map›Paper›PMID 31467512›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2019

Antinociceptive effect of PnTx4(5-5), a peptide from

Camila Franco Batista Oliveira, Daniela Pereira Alves, Bruna Luiza Emerich, Suely Gomes de Figueiredo, Marta do Nascimento Cordeiro, Márcia Helena Borges, Michael Richardson, Adriano Monteiro de Castro Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Spinal antinociceptive effect of the PnTx4(5-5) peptide is possibly mediated by the NMDA autoreceptors.The journal of venomous animals and toxins including tropical diseases · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Comparative venomic profiles of three spiders of the genusThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  7. Review
  8. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  9. Article
  10. Gene sequence analysis of toxins from the spiderThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  11. Intravitreal injection of peptides PnPa11 and PnPa13, derivatives ofThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Camila Franco Batista OliveiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
Daniela Pereira AlvesDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
Bruna Luiza EmerichDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
Suely Gomes de FigueiredoDepartamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espirito Santo (UFES), Vitória (ES), Brasil.
Marta do Nascimento CordeiroCentro de Pesquisa e Desenvolvimento Professor Carlos Diniz, Fundação Ezequiel Dias (FUNED), Belo Horizonte, MG, Brasil.
Márcia Helena BorgesCentro de Pesquisa e Desenvolvimento Professor Carlos Diniz, Fundação Ezequiel Dias (FUNED), Belo Horizonte, MG, Brasil.
Michael RichardsonCentro de Pesquisa e Desenvolvimento Professor Carlos Diniz, Fundação Ezequiel Dias (FUNED), Belo Horizonte, MG, Brasil.
Adriano Monteiro de Castro PimentaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
Igor Dimitri Gama DuarteDepartamento de Fisiologia e Farmacologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
Maria Elena de LimaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.ORCID 0000-0001-6185-4032
Universidade Federal de Minas Gerais · BREzequiel Dias Foundation · BRUniversidade Federal do Espírito Santo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe venom of

methodsThe antinociceptive activity was evaluated using the paw pressure test in rats, after hyperalgesia induction with intraplantar injection of carrageenan or prostaglandin E

resultsPnTx4(5-5), subcutaneously injected, was able to reduce the hyperalgesia induced by PGE

conclusionThe antinociceptive effect for PnTx4(5-5) was demonstrated against different rat pain models, i.e. induced by PGE

Indexed as

AntinociceptionglutamatePhoneutria nigriventerPnTx4(5-5)spider toxinΓ-ctenitoxin-Pn1a

Identifiers

PMID31467512
PMCPMC6706083
OpenAlexW2968288113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.