Evidence map›Paper›PMID 31467450›Full record

ReviewNature reviews. Neuroscience2019

Cortical mechanisms of spatial hearing.

Kiki van der Heijden, Josef P Rauschecker, Beatrice de Gelder, Elia Formisano

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. The larvalScience advances · 2026
    Article
  2. Infant Cortical Tracking of Speech Shows Emerging Spatial Release from Masking in the First Year of Life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. The larvalbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kiki van der HeijdenDepartment of ENT/Audiology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine, and Life Sciences, Maastricht University Medical Center, Maastricht, Netherlands. kiki.vanderheijden@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0003-4516-7907
Josef P RauscheckerLaboratory of Integrative Neuroscience and Cognition, Department of Neuroscience, Georgetown Medical Center, Washington, DC, USA.
Beatrice de GelderDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.
Elia FormisanoDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.ORCID http://orcid.org/0000-0001-5008-2460

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Sensory-motor integration in the auditory dorsal streamR01DC014989 · NIDCD · GEORGETOWN UNIVERSITY · PI RAUSCHECKER, JOSEF P · 2016 to 2025
$4.7M
Sensory cortical organization and cross-modal plasticity in blind subjectsR01EY018923 · NEI · GEORGETOWN UNIVERSITY · PI RAUSCHECKER, JOSEF P · 2009 to 2016
$2.4M
NEI NIH HHS R01 EY018923NICHD NIH HHS U54 HD090257NIDCD NIH HHS R01 DC014989
6 · The paper itself

Abstract

Humans and other animals use spatial hearing to rapidly localize events in the environment. However, neural encoding of sound location is a complex process involving the computation and integration of multiple spatial cues that are not represented directly in the sensory organ (the cochlea). Our understanding of these mechanisms has increased enormously in the past few years. Current research is focused on the contribution of animal models for understanding human spatial audition, the effects of behavioural demands on neural sound location encoding, the emergence of a cue-independent location representation in the auditory cortex, and the relationship between single-source and concurrent location encoding in complex auditory scenes. Furthermore, computational modelling seeks to unravel how neural representations of sound source locations are derived from the complex binaural waveforms of real-life sounds. In this article, we review and integrate the latest insights from neurophysiological, neuroimaging and computational modelling studies of mammalian spatial hearing. We propose that the cortical representation of sound location emerges from recurrent processing taking place in a dynamic, adaptive network of early (primary) and higher-order (posterior-dorsal and dorsolateral prefrontal) auditory regions. This cortical network accommodates changing behavioural requirements and is especially relevant for processing the location of real-life, complex sounds and complex auditory scenes.

Indexed as

Acoustic StimulationAnimalsAuditory CortexAuditory PathwaysHearingHumansSound Localization

Identifiers

PMID31467450
PMCPMC7081609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.