Evidence map›Paper›PMID 31467426›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2019

Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl

Florian P Reiter, Liangtao Ye, Florian Bösch, Ralf Wimmer, Renate Artmann, Andreas Ziesch, Veronika Kanitz, Doris Mayr, Christian J Steib, Michael Trauner and 6 more

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Signaling Pathways Involved in Diabetic Renal Fibrosis.Frontiers in cell and developmental biology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Florian P ReiterDepartment of Medicine II, University Hospital, LMU, Munich, Germany. Florian.Reiter@med.uni-muenchen.de.
Liangtao YeDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Florian BöschDepartment of General, Visceral, and Transplantation Surgery, University Hospital, LMU, Munich, Germany.
Ralf WimmerDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Renate ArtmannDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Andreas ZieschDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Veronika KanitzInstitute of Pathology, University of Munich, Munich, Germany.
Doris MayrInstitute of Pathology, University of Munich, Munich, Germany.
Christian J SteibDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Michael TraunerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Ivonne RegelDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Alexander L GerbesDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Julia MayerleDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Simon HohenesterDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Enrico N de ToniDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Gerald DenkDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DEMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cirrhosis is a life-threatening consequence of liver fibrosis. The aim of this study was to investigate the antifibrotic potential of clinically available vitamin D analogs compared to that of calcitriol in vitro and in vivo. Murine hepatic stellate cells, Kupffer cells, and human LX-2 cells were treated with vitamin D analogs, and the profibrotic behavior of these cells was studied. In vivo liver fibrosis was induced using CCl

Indexed as

AnimalsCalcitriolCalciumCarbon TetrachlorideCell LineDrug Evaluation, PreclinicalErgocalciferolsHepatic Stellate CellsHumansKupffer CellsLiver CirrhosisMaleMice, Inbred C57BLPrimary Cell CultureTransforming Growth Factor betaVitamin DCalcitriolCalciumCarbon TetrachlorideErgocalciferolsparicalcitolTransforming Growth Factor betaVitamin D

Identifiers

PMID31467426
OpenAlexW2971220450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.