ArticleMolecular psychiatry2021
Variation of HbA1c affects cognition and white matter microstructure in healthy, young adults.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07073781 (A Double-blind Placebo-controlled Exploratory Trial to Assess the Impact of Daily Lab4P Probiotic Supplementation on Cognitive Performance and Metabolic Regulation in Overweight Young Adults With Impaired Glucose Regulation), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-blind Placebo-controlled Exploratory Trial to Assess the Impact of Daily Lab4P Probiotic Supplementation on Cognitive Performance and Metabolic Regulation in Overweight Young Adults With Impaired Glucose Regulation
Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- HbA1c and Cognitive Functioning Across Bipolar Disorder, Recurrent Major Depressive Disorder, and Schizophrenia: Findings from a Non-Diabetic Sample.Brain sciences · 2026Article
- Association of glymphatic function with 40-Hz neural oscillations, systemic metabolic markers, and cognitive performance in healthy aging adults: An EEG and MRI study.Translational psychiatry · 2026Article
- Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate-to-severe white matter hyperintensities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Impact of glycemic control on brain microstructure in type 2 diabetes mellitus: insights from diffusion tensor imaging.BMC medical imaging · 2025Article
- Effects of glycaemic control on memory performance, hippocampal volumes and depressive symptomology.Diabetology & metabolic syndrome · 2024Article
- The Possible Associations between Tauopathies and Atherosclerosis, Diabetes Mellitus, Dyslipidemias, Metabolic Syndrome and Niemann-Pick Disease.Diagnostics (Basel, Switzerland) · 2024Review
- Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults.npj metabolic health and disease · 2024Article
- The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance.Scientific reports · 2024Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Association between elevated glycosylated hemoglobin and cognitive impairment in older Korean adults: 2009-2010 Ansan cohort of the Korean genome and epidemiology study.Frontiers in public health · 2024Article
- Regional Vulnerability of the Corpus Callosum in the Context of Cardiovascular Risk.Journal of geriatric psychiatry and neurology · 2023Article
- Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents.Brain structure & function · 2023Article
- Altered dynamic functional architecture in type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
- Baseline associations between biomarkers, cognitive function, and self-regulation indices in the Cognitive and Self-regulatory Mechanisms of Obesity Study.Obesity science & practice · 2021Article
- MASiVar: Multisite, multiscanner, and multisubject acquisitions for studying variability in diffusion weighted MRI.Magnetic resonance in medicine · 2021Article
- Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy.Journal of psychiatry & neuroscience : JPN · 2021Article
- Tractography in Type 2 Diabetes Mellitus With Subjective Memory Complaints: A Diffusion Tensor Imaging Study.Frontiers in neuroscience · 2021Article
- Sleep duration is associated with white matter microstructure and cognitive performance in healthy adults.Human brain mapping · 2020Observational
- Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder.Molecular psychiatry · 2020Article
- Associations Between Physical Fitness and Brain Structure in Young Adulthood.Frontiers in psychology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
The metabolic serum marker HbA1c has been associated with both impaired cognitive performance and altered white matter integrity in patients suffering from diabetes mellitus. However, it remains unclear if higher levels of HbA1c might also affect brain structure and function in healthy subjects. With the present study we therefore aimed to investigate the relationship between HbA1c levels and cognitive performance as well as white matter microstructure in healthy, young adults. To address this question, associations between HbA1c and cognitive measures (NIH Cognition Toolbox) as well as DTI-derived imaging measures of white matter microstructure were investigated in a publicly available sample of healthy, young adults as part of the Humane Connectome Project (n = 1206, mean age = 28.8 years, 45.5% male). We found that HbA1c levels (range 4.1-6.3%) were significantly inversely correlated with measures of cognitive performance. Higher HbA1c levels were associated with significant and widespread reductions in fractional anisotropy (FA) controlling for age, sex, body mass index, ethnicity, and education. FA reductions were furthermore found to covary with measures of cognitive performance. The same pattern of results could be observed in analyses restricted to participants with HBA1c levels below 5.7%. The present study demonstrates that low-grade HbA1c variation below diagnostic threshold for diabetes is related to both cognitive performance and white matter integrity in healthy, young adults. These findings highlight the detrimental impact of metabolic risk factors on brain physiology and underscore the importance of intensified preventive measures independent of the currently applied diagnostic HbA1c cutoff scores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.