ArticleScientific reports2019
Phenotypic switching in Candida tropicalis alters host-pathogen interactions in a Galleria mellonella infection model.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Co-infection with systemic candidiasis and diphtheritic aspergillosis in a Buffalo calf.Veterinary research communications · 2025Article
- In Vitro Fluconazole Exposure Promotes Switch Phenotypes With Altered Virulence Traits in the Pathogenic YeastIndian journal of microbiology · 2025Article
- Clinical Isolate ofOpen journal of medical microbiology · 2025Article
- Review
- Article
- HYPHAEdelity: a quantitative image analysis tool for assessing peripheral whole colony filamentation.FEMS yeast research · 2022Article
- Serial passage in an insect host indicates genetic stability of the human probioticEvolution, medicine, and public health · 2022Article
- Review
- Article
- Virulence of ClinicalPathogens (Basel, Switzerland) · 2021Article
- Changes in Adhesion of Candida tropicalis Clinical Isolates Exhibiting Switch Phenotypes to Polystyrene and HeLa Cells.Mycopathologia · 2021Article
- Mechanism of Candida pathogenesis: revisiting the vital drivers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
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Authors and funding
8 authors.
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Abstract
Candida tropicalis is a human pathogen associated with high mortality rates. We have reported a switching system in C. tropicalis consisting of five morphotypes - the parental, switch variant (crepe and rough), and revertant (crepe and rough) strains, which exhibited altered virulence in a Galleria mellonella model. Here, we evaluate whether switching events may alter host-pathogen interactions by comparing the attributes of the innate responses to the various states. All switched strains induced higher melanization in G. mellonella larvae than that induced by the parental strain. The galiomicin expression was higher in the larvae infected with the crepe and rough morphotypes than that in the larvae infected with the parental strain. Hemocytes preferentially phagocytosed crepe variant cells over parental cells in vitro. In contrast, the rough variant cells were less phagocytosed than the parental strain. The hemocyte density was decreased in the larvae infected with the crepe variant compared to that in the larvae infected with the parental strain. Interestingly, larvae infected with the revertant of crepe restored the hemocyte density levels that to those observed for larvae infected with the parental strain. Most of the switched strains were more resistant to hemocyte candidacidal activity than the parental strain. These results indicate that the switch states exhibit similarities as well as important differences during infection in a G. mellonella model.
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