Observational studyScientific reports2019
Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.
Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.Systematic reviews · 2023Pooled it
- Hyponatremia correction is associated with increased brain-derived neurotrophic factor levels: A pilot secondary analysis of a randomized, double-blind, placebo-controlled, crossover trial.Journal of neuroendocrinology · 2026Trial
- Addressing Inpatient Hyponatremia Through Targeted Automatic E-consults: A Pilot Randomized Trial.Journal of general internal medicine · 2025Trial
- Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels.bioRxiv : the preprint server for biology · 2026Article
- Cognition and fall assessment after recovery from syndrome of inappropriate anti diuresis.Endocrine · 2025Article
- Treatment with antidepressant drugs and hyponatremia: a network meta-analysis.Journal of endocrinological investigation · 2025Article
- Characteristics, management and outcomes of patients with hyponatraemia presenting to an Irish tertiary hospital.Endocrine connections · 2025Article
- Hyponatremia in geriatric patients.Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- Is hyponatremia after geriatric trauma the new frailty?Trauma surgery & acute care open · 2025Article
- Associations between Baseline Hyponatremia and Activities of Daily Living and Muscle Health in Convalescent Stroke Patients.Progress in rehabilitation medicine · 2024Article
- Analysis of current situation and influencing factors of cognitive dysfunction associated with type 2 diabetes and follow-up study on treatment effectiveness.Frontiers in neurology · 2024Article
- Serum sodium improvement: change in Comprehensive Geriatric Assessment parameters in geriatric patients with hyponatremia.BMC geriatrics · 2023Article
- Serum sodium, cognition and incident dementia in the general population.Age and ageing · 2023Article
- Morbidity Associated with Chronic Hyponatremia.Journal of clinical medicine · 2023Article
- Article
- The management of acute and chronic hyponatraemia.Therapeutic advances in endocrinology and metabolism · 2022Review
- Restoration of dysnatremia and acute kidney injury benefits outcomes of acute geriatric inpatients.Scientific reports · 2021Observational
- Assocıatıons between mıld hyponatremıa and gerıatrıc syndromes ın outpatıent settıngs.International urology and nephrology · 2021Article
- Serum sodium in relation to various domains of cognitive function in the elderly US population.BMC geriatrics · 2021Article
- Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive function, motor performance and mood stability was applied on admission and at discharge. Changes of individual test results (Δ) were analyzed and normonatremic patients matched for age, gender, and ADL served as reference group. Most CGA test results improved. The improvement was more pronounced in the hyponatremia group with respect to ADL (ΔADL: 14.3 ± 17.1 vs. 9.8 ± 14.7; p = 0.002) and MMSE (ΔMMSE: 1.8 ± 3.0 vs. 0.7 ± 1.9; p = 0.002). Effect sizes were small (i.e., >0.2) in the overall analysis for ΔADL and ΔMMSE and moderate (i.e., >0.5) for ΔMMSE in the euvolemic subgroup. Beneficial effects on ΔADL and ΔMMSE were only observed in the subgroup of patients in which [Na
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Registered trials
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