Evidence map›Paper›PMID 31467358›Full record

ArticleScientific reports2019

Thermal Perceptual Thresholds are typical in Autism Spectrum Disorder but Strongly Related to Intra-individual Response Variability.

Zachary J Williams, Michelle D Failla, Samona L Davis, Brynna H Heflin, Christian D Okitondo, David J Moore, Carissa J Cascio

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Trial-to-Trial Variability in Electrodermal Activity to Odor in Autism.Autism research : official journal of the International Society for Autism Research · 2020
    Article
  14. The Dutch Sensory Perception Quotient-Short in adults with and without autism.Autism : the international journal of research and practice · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary J WilliamsMedical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA. zachary.j.williams@vanderbilt.edu.ORCID http://orcid.org/0000-0001-7646-423X
Michelle D FaillaDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.
Samona L DavisDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.
Brynna H HeflinDepartment of Psychology, Florida International University, Miami, FL, 33199, USA.
Christian D OkitondoDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.
David J MooreResearch Centre for Brain and Behaviour, Liverpool John Moores University, Liverpool, L3 5UA, UK.
Carissa J CascioDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
Sensorimotor integration governing facial expression production in autism.R01MH102272 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J · 2014 to 2023
$4.3M
Mapping Thalamocortical Networks Across Development in ASDR21MH101321 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J, WOODWARD, NEIL D. · 2014 to 2015
$432k
NCATS NIH HHS TL1 TR002244NCATS NIH HHS UL1 TR000445NICHD NIH HHS U54 HD083211NIGMS NIH HHS T32 GM007347NIMH NIH HHS R01 MH102272NIMH NIH HHS R21 MH101321NIMH NIH HHS T32 MH018921U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM007347
6 · The paper itself

Abstract

Individuals with autism spectrum disorder (ASD) are often reported to exhibit an apparent indifference to pain or temperature. Leading models suggest that this behavior is the result of elevated perceptual thresholds for thermal stimuli, but data to support these assertions are inconclusive. An alternative proposal suggests that the sensory features of ASD arise from increased intra-individual perceptual variability. In this study, we measured method-of-limits warm and cool detection thresholds in 142 individuals (83 with ASD, 59 with typical development [TD], aged 7-54 years), testing relationships with diagnostic group, demographics, and clinical measures. We also investigated the relationship between detection thresholds and a novel measure of intra-individual (trial-to-trial) threshold variability, a putative index of "perceptual noise." This investigation found no differences in thermal detection thresholds between individuals with ASD and typical controls, despite large differences between groups in sensory reactivity questionnaires and modest group differences in intra-individual variability. Lower performance IQ, male sex, and higher intra-individual variability in threshold estimates were the most significant predictors of elevated detection thresholds. Although no psychophysical measure was significantly correlated with questionnaire measures of sensory hyporeactivity, large intra-individual variability may partially explain the elevated psychophysical thresholds seen in a subset of the ASD population.

Indexed as

Sensory ThresholdsTemperatureAdolescentAdultAutism Spectrum DisorderChildFemaleHumansMaleRegression Analysis

Identifiers

PMID31467358
PMCPMC6715703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.