ArticleNature communications2019
A null model of the mouse whole-neocortex micro-connectome.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- Article
- Generating brain-wide connectome using synthetic axonal morphologies.Nature communications · 2025Article
- Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Effects of connectivity hyperalignment (CHA) on estimated brain network properties: from coarse-scale to fine-scale.bioRxiv : the preprint server for biology · 2024Article
- Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint.Nature communications · 2024Article
- Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Simulations of cortical networks using spatially extended conductance-based neuronal models.The Journal of physiology · 2023Review
- Unsupervised classification of brain-wide axons reveals neuronal projection blueprint.Research square · 2023Article
- The energy challenges of artificial superintelligence.Frontiers in artificial intelligence · 2023Article
- A parcellation scheme of mouse isocortex based on reversals in connectivity gradients.Network neuroscience (Cambridge, Mass.) · 2023Article
- Would you exchange your soul for immortality?-existential meaning and afterlife beliefs predict mind upload approval.Frontiers in psychology · 2023Article
- Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees.PLoS computational biology · 2022Article
- Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation.Journal of neural engineering · 2022Article
- Digital Brain Maps and Virtual Neuroscience: An Emerging Role for Light-Sheet Fluorescence Microscopy in Drug Development.Frontiers in neuroscience · 2022Review
- Computational Concepts for Reconstructing and Simulating Brain Tissue.Advances in experimental medicine and biology · 2022Article
- Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Greedy low-rank algorithm for spatial connectome regression.Journal of mathematical neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale connectomics, studying connectivity between individual neurons. We combine these two complementary views of connectomics to build a first draft statistical model of the micro-connectome of a whole mouse neocortex based on available data on region-to-region connectivity and individual whole-brain axon reconstructions. This process reveals a targeting principle that allows us to predict the innervation logic of individual axons from meso-scale data. The resulting connectome recreates biological trends of targeting on all scales and predicts that an established principle of scale invariant topological organization of connectivity can be extended down to the level of individual neurons. It can serve as a powerful null model and as a substrate for whole-brain simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.