ArticleNature communications2019
GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Genome-wide association studies meta-analysis uncovers NOJO and SGS3 novel genes involved in Arabidopsis thaliana primary root development and plasticity.Molecular biology reports · 2024Pooled it
- Meta-Analysis of Iron Excess Stress in Rice: Genes and Mechanisms of Tolerance to Acidic Soil.Physiologia plantarumPooled it
- Modulation of GSNOR activity for improved NO homeostasis and flood resilience in plants.Plant signaling & behavior · 2026Review
- MPK3-mediated phosphorylation inactivates MYB4 to promote FIT-dependent iron acquisition.EMBO reports · 2026Article
- In situ submitochondrial mapping in living plants via Hessian Structured Illumination Microscopy.The New phytologist · 2026Article
- The Central Role of GSNOR: Decoding Nitric Oxide Signaling for Crop Stress Tolerance.International journal of molecular sciences · 2025Review
- Impact of Mycorrhiza Inoculations and Iron Amino Chelate on Growth and Physiological Changes of Cucumber Seedlings Across Different pH Levels.Plants (Basel, Switzerland) · 2025Article
- ANAC044 orchestrates mitochondrial stress signaling to trigger iron-induced stem cell death in root meristems.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ion toxicity in waterlogged soils: mechanisms of root response and adaptive strategies.Frontiers in plant science · 2025Review
- Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification.Nature communications · 2024Article
- Candidate Genes and Favorable Haplotypes Associated with Iron Toxicity Tolerance in Rice.International journal of molecular sciences · 2024Article
- Root Walker: an automated pipeline for large scale quantification of early root growth responses at high spatial and temporal resolution.The Plant journal : for cell and molecular biology · 2024Article
- NO Is Not the Same as GSNO in the Regulation of Fe Deficiency Responses by Dicot Plants.International journal of molecular sciences · 2023Review
- Redox Signaling in Plant Heat Stress Response.Antioxidants (Basel, Switzerland) · 2023Review
- Iron Availability and Homeostasis in Plants: A Review of Responses, Adaptive Mechanisms, and Signaling.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Combined Approach of GWAS and Phylogenetic Analyses to Identify New Candidate Genes That Participate inPlants (Basel, Switzerland) · 2022Article
- Genome-Wide Association Study of Zinc Toxicity Tolerance within a Rice Core Collection (Plants (Basel, Switzerland) · 2022Article
- An allelic variant in the ACS7 gene promotes primary root growth in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.Nature communications · 2022Article
- Transcriptomic Analysis Revealed Reactive Oxygen Species Scavenging Mechanisms Associated With Ferrous Iron Toxicity in Aromatic Keteki Joha Rice.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitative locus for root tolerance to Fe-toxicity in Arabidopsis using genome-wide association studies and allelic complementation. These variants act largely through transcript level regulation. We further show that the elevated nitric oxide is essential for Fe-dependent redox toxicity. GSNOR maintains root meristem activity and prevents cell death via inhibiting Fe-dependent nitrosative and oxidative cytotoxicity. GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants. Overall, this study shows that genetic or chemical modulation of the nitric oxide pathway can broadly modify Fe-toxicity tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.