ArticleNeurology2019
Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 101 citations in OpenAlex.
- Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications.BMJ open · 2023Trial
- Electroencephalography of mechanically ventilated patients at high risk of delirium.Acta neurologica Scandinavica · 2021Trial
- Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery.Bioscience reports · 2020Trial
- A Personalized, Symptom-Based Approach to Boost Research Participation in Hospitalized Older Adults.Journal of the American Geriatrics Society · 2026Article
- Resting-state EEG for continuous prognostic monitoring and prediction of coma recovery after acute brain injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Zuranolone mitigates delirium-like bispectral EEG changes, behavioral deficits, and neuroinflammation across surgical and inflammatory mouse models and age groups.bioRxiv : the preprint server for biology · 2026Article
- Video-based Detection of Delirium in Hospitalized Adults.medRxiv : the preprint server for health sciences · 2026Article
- Video-based detection of Delirium in hospitalized adults.PLOS digital health · 2026Article
- Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach.GeroScience · 2026Observational
- Review
- Point-of-care electroencephalography for prediction of postoperative delirium in older adults undergoing elective surgery: protocol for a prospective cohort study.Biology methods & protocols · 2026Review
- Role of Electroencephalographic Biomarkers as Predictors of Post-Stroke Cognitive Outcomes in Patients with Cerebral Infarction: Literature Review.Neuropsychiatric disease and treatment · 2026Review
- Bedside EEG for rapid diagnosis of delirium.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Electrographic Features of Catatonia With or Without Comorbid Delirium.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative Delirium.Research square · 2025Article
- Serum NSE and EEG sleep figures for prognostication of short-term outcomes in adults with severe COVID-19 pneumonia: a prospective single-center study.Scientific reports · 2025Article
- [Incidence and factors associated with delirium in an Emergency Department].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- Neurological, metabolic and inflammatory phenotypes in a mouse model of ECHS1 deficiency.Brain communications · 2025Article
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
- Electroencephalography based delirium screening in acute supratentorial stroke.BMC neurology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine which findings on routine clinical EEGs correlate with delirium severity across various presentations and to determine whether EEG findings independently predict important clinical outcomes.
methodsWe prospectively studied a cohort of nonintubated inpatients undergoing EEG for evaluation of altered mental status. Patients were assessed for delirium within 1 hour of EEG with the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) and 3D-CAM severity score. EEGs were interpreted clinically by neurophysiologists, and reports were reviewed to identify features such as theta or delta slowing and triphasic waves. Generalized linear models were used to quantify associations among EEG findings, delirium, and clinical outcomes, including length of stay, Glasgow Outcome Scale scores, and mortality.
resultsWe evaluated 200 patients (median age 60 years, IQR 48.5-72 years); 121 (60.5%) met delirium criteria. The EEG finding most strongly associated with delirium presence was a composite of generalized theta or delta slowing (odds ratio 10.3, 95% confidence interval 5.3-20.1). The prevalence of slowing correlated not only with overall delirium severity (
conclusionsGeneralized slowing on routine clinical EEG strongly correlates with delirium and may be a valuable biomarker for delirium severity. In addition, generalized EEG slowing should trigger elevated concern for the prognosis of patients with altered mental status.
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