Evidence map›Paper›PMID 31467248›Full record

ArticleThe Plant cell2019

Deep Conservation of

Michal Lieberman-Lazarovich, Chen Yahav, Alon Israeli, Idan Efroni

Open access · hybridAbstract read
In one paragraph

Article in The Plant cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
10.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. aBIOTECH · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Conserved regions upstream ofFrontiers in plant science · 2025
    Article
  12. Review
  13. Article
  14. A non-canonicalFrontiers in plant science · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Transcriptional Regulation of zma-International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michal Lieberman-LazarovichInstitute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, The Hebrew University, Rehovot 7610001, Israel.ORCID 0000-0002-1776-8257
Chen YahavInstitute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, The Hebrew University, Rehovot 7610001, Israel.ORCID 0000-0003-1750-9842
Alon IsraeliInstitute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, The Hebrew University, Rehovot 7610001, Israel.ORCID 0000-0002-3339-2042
Idan EfroniInstitute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, The Hebrew University, Rehovot 7610001, Israel efroni.idan@mail.huji.ac.il.ORCID 0000-0002-0219-8685
Hebrew University of Jerusalem · IL

Funding

Howard Hughes Medical Institute 55008730
6 · The paper itself

Abstract

Phytohormones regulate many aspects of plant life by activating transcription factors (TFs) that bind sequence-specific response elements (REs) in regulatory regions of target genes. Despite their short length, REs are degenerate, with a core of just 3 to 4 bp. This degeneracy is paradoxical, as it reduces specificity and REs are extremely common in the genome. To study whether RE degeneracy might serve a biological function, we developed an algorithm for the detection of regulatory sequence conservation and applied it to phytohormone REs in 45 angiosperms. Surprisingly, we found that specific RE variants are highly conserved in core hormone response genes. Experimental evidence showed that specific variants act to regulate the magnitude and spatial profile of hormonal response in Arabidopsis (

Indexed as

Abscisic AcidAlgorithmsArabidopsisBase SequenceConserved SequenceCytokininsDNA, PlantGene Expression Regulation, PlantGenes, PlantGenome, PlantMagnoliopsidaPlant Growth RegulatorsPlant ProteinsPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidResponse ElementsAbscisic AcidCytokininsDNA, PlantPlant Growth RegulatorsPlant Proteins

Identifiers

PMID31467248
PMCPMC6881130
OpenAlexW2970803416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.