Evidence map›Paper›PMID 31467227›Full record

ArticleCancer genomics & proteomics

Association of Leukemia Target Genes

Jing Li, Wenqi Zhang, Weidong Liu, Jarrett Rong, Yuhan Chen, Weikuan Gu, Wei Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jing LiDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A.
Wenqi ZhangDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A.
Weidong LiuDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A.
Jarrett RongDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A.
Yuhan ChenGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China.
Weikuan GuDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A. wgu@uthsc.edu zhangwei666cn@foxmail.com.
Wei ZhangDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, U.S.A. wgu@uthsc.edu zhangwei666cn@foxmail.com.
Hebei Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNQiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin C has been used in combination with several target genes in the treatment of leukemia. Tet methylcytosine dioxygenase (Tet2), B-cell lymphoma 2 (Bcl2), and solute carrier family 23 member 2 (Slc23a2) are the major target genes in the treatment of leukemia and are relevant to vitamin C. MATERIALS AND

methodsUsing whole-genome expression profiles from mouse livers, the expression quantitative trait locus (eQTL), correlation matrix, and gene network graph were constructed with probes from each of these three genes and with their relative genes. The function of key genes was examined by their pathways and reported information. The results indicated that although direct correlations among their expression levels were not strong, alternative connecting pathways were discovered. By comparing the expression levels of one probe with known sequences from each of the three genes, we identified several key genes, induced myeloid leukemia cell differentiation protein (Mcl1), far upstream element-binding protein 1 (Fubp1), and tumor protein D52-like 2 (Tpd52l2), which play important roles in acute lymphocytic leukemia and acute myelocytic leukemia. In conclusion, Alternative pathways and key genes that connect Tet2, Bcl2, and Slc23a2 for their therapeutic applications with vitamin C were identified.

Indexed as

AnimalsAscorbic AcidDioxygenasesDNA-Binding ProteinsHumansLeukemia, Myeloid, AcuteLiverMiceMyeloid Cell Leukemia Sequence 1 ProteinPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Quantitative Trait LociRNA-Binding ProteinsSodium-Coupled Vitamin C TransportersAscorbic AcidBcl2 protein, mouseDioxygenasesDNA-Binding Proteinsfubp1 protein, mouseMcl1 protein, mouseMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2RNA-Binding ProteinsSlc23a2 protein, mouseSodium-Coupled Vitamin C TransportersTet2 protein, mousealternative pathwayseQTL mappingkey genesleukemiaVitamin C

Identifiers

PMID31467227
PMCPMC6727075
OpenAlexW2971332026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.