Evidence map›Paper›PMID 31467128›Full record

ArticleHaematologica2020

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and

Chantal Kroone, Mariska Vos, Timo Rademakers, Marijke Kuijpers, Mark Hoogenboezem, Jaap van Buul, Johan W M Heemskerk, Wolfram Ruf, Astrid van Hylckama Vlieg, Henri H Versteeg and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Chantal KrooneThe Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (UMC), Leiden, the Netherlands.
Mariska VosDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Timo RademakersDepartment of Molecular Cell Biology, Sanquin Research, Amsterdam, the Netherlands.
Marijke KuijpersDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht UMC, Maastricht, The Netherlands.
Mark HoogenboezemDepartment of Molecular Cell Biology, Sanquin Research, Amsterdam, the Netherlands.
Jaap van BuulDepartment of Molecular Cell Biology, Sanquin Research, Amsterdam, the Netherlands.
Johan W M HeemskerkDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht UMC, Maastricht, The Netherlands.
Wolfram RufDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Astrid van Hylckama VliegDepartment of Clinical Epidemiology, Leiden UMC, Leiden, the Netherlands.
Henri H VersteegThe Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (UMC), Leiden, the Netherlands.
Marie-José GoumansDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Carlie J M de VriesDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Kondababu KurakulaDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands k.b.kurakula@lumc.nl.
INVENT Consortium
Leiden University Medical Center · NLSanquin · NLUniversity of Amsterdam · NLLeiden University · NLMaastricht University · NLMaastricht University Medical Centre · NLScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bleeding disorders and thrombotic complications are major causes of morbidity and mortality with many cases being unexplained. Thrombus formation involves aberrant expression and activation of tissue factor (TF) in vascular endothelial and smooth muscle cells. Here, we sought to identify factors that modulate

Indexed as

ThromboplastinVenous ThrombosisAnimalsGenetic VariationHumansLIM-Homeodomain ProteinsMiceMuscle ProteinsTranscription FactorsFHL2 protein, humanFhl2 protein, mouseLIM-Homeodomain ProteinsMuscle ProteinsThromboplastinTranscription Factors

Identifiers

PMID31467128
PMCPMC7271603
OpenAlexW2970361245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.