Evidence map›Paper›PMID 31467051›Full record

ArticleBMJ open2019

The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study.

Anastasia N Iliadou, Anna Sara Öberg, Jessica Pege, Kenny A Rodriguez-Wallberg, Jan I Olofsson, Jan Holte, Håkan Wramsby, Margaretha Wramsby, Sven Cnattingius, Carolyn E Cesta

Abstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. DNA methylation differences at birth after conception through ART.Human reproduction (Oxford, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anastasia N IliadouDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anna Sara ÖbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jessica PegeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kenny A Rodriguez-WallbergDepartment of Reproductive Medicine, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.
Jan I OlofssonDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0534-5158
Jan HolteCarl von Linne Kliniken, Uppsala, Sweden.
Håkan WramsbyLivio Fertilitetscentrum Kungsholmen, Stockholm, Sweden.
Margaretha WramsbyLivio Fertilitetscentrum Gärdet, Stockholm, Sweden.
Sven CnattingiusClinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Carolyn E CestaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden carolyn.cesta@ki.se.ORCID 0000-0001-5759-9366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome.

participantsRecruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study. FINDINGS TO DATE: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis. FUTURE PLANS: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart.

Indexed as

DNA MethylationEpigenesis, GeneticFertilization in VitroLife StyleAdultCohort StudiesFemaleFetal BloodHumansInfant, NewbornMaleMedical Record LinkagePregnancyPregnancy OutcomePregnancy RateProspective Studiesassisted reproductive techniquesepigeneticsinfertilityin vitro fertilisationlifestyle

Identifiers

PMID31467051
PMCPMC6720339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.