Evidence map›Paper›PMID 31466961›Full record

ArticleBMJ case reports2019

Ischaemic stroke in a patient with myasthaenic crisis and antiphospholipid antibody syndrome.

Jose Danilo B Diestro, Maria Kristina C Dorotan, Vida Margarette D Andal, Arnolfo B Tomas, Romergryko G Geocadin, Ma Epifania V Collantes

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jose Danilo B DiestroDepartment of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.ORCID http://orcid.org/0000-0001-8450-2021
Maria Kristina C DorotanDepartment of Neurology, Lewis Katz School ofMedicine, Temple University, Philadelphia, Pennsylvania, USA.
Vida Margarette D AndalDepartment of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Arnolfo B TomasDepartment of Medicine, College of Medicine and Philippines General Hospital, University of the Philippines Manila, Manila, Philippines.
Romergryko G GeocadinDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ma Epifania V CollantesDepartment of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Philippine General Hospital · PHJohns Hopkins University · USTemple University · USUniversity of the Philippines Manila · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While autoimmune diseases have been frequently found to coexist in the same patients, the co-occurrence of myasthaeniagravis and antiphospholipid antibody syndrome (APAS) has only been reported in eight cases. We present a case of a 46-year-old Filipina who developed ischaemic stroke while admitted at the neurocritical unit for myasthaenic crisis. She was successfully thrombolysed with intravenous recombinant tissue plasminogen activator (rTPA), given a regimen of intravenous Ig and a dose of cyclophosphamide prior to discharge. Extensive workup revealed APAS to be the aetiology of her stroke. Twenty-one months into her follow-up, she is doing well with a modified Rankin Score of 0. Our case suggests that rTPA followed by immunomodulators may be given safely in myasthaenic crisis patients who develop ischaemic stroke. We emphasise the importance of doing a comprehensive neurological evaluation in agitated patients in the critical care unit.

Indexed as

Administration, IntravenousAntiphospholipid SyndromeBrain IschemiaCritical CareFemaleFibrinolytic AgentsHumansMagnetic Resonance ImagingMiddle AgedMyasthenia GravisStrokeThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeFibrinolytic AgentsTissue Plasminogen Activatorimmunologyneurologyneuromuscular diseasestroke

Identifiers

PMID31466961
PMCPMC6721000
OpenAlexW2970515641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.