ArticleInternational journal of environmental research and public health2019
Education and Lifestyle Factors Are Associated with DNA Methylation Clocks in Older African Americans.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index.Journal of internal medicine · 2022Pooled it
- Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health.Circulation research · 2021Trial
- The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study.Clinical epigenetics · 2026Article
- Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults.Clinical epigenetics · 2026Article
- Alcohol Consumption and DNA Methylation in a Mediterranean Cohort: A Focus on Oxidative Stress and Aging Biomarkers.Antioxidants (Basel, Switzerland) · 2026Article
- Association of Smoking Behavior, Intensity, and Time Since Cessation with Epigenetic Aging Biomarkers: Results from NHANES 1999-2002.medRxiv : the preprint server for health sciences · 2025Article
- Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity.BMC medicine · 2025Article
- Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics.iScience · 2025Article
- Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry.Aging cell · 2025Article
- Global burden of motor neuron disease: unraveling socioeconomic disparities, aging dynamics, and divergent future trajectories (1990-2040).Journal of neurology · 2025Review
- Adolescent empathy and epigenetic aging in adulthood: Substance use as a mediator.Developmental psychology · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.European journal of epidemiology · 2025Article
- Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future.Aging and disease · 2024Review
- Article
- Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.Aging cell · 2024Article
- Sociodemographic and Lifestyle Factors and Epigenetic Aging in US Young Adults: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.GeroScience · 2024Article
- Maternal prenatal social experiences and offspring epigenetic age acceleration from birth to mid-childhood.Annals of epidemiology · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and are associated with a variety of age-related chronic diseases and all-cause mortality. Examining the relationship between education and lifestyle risk factors for age-related diseases and multiple DNAm clocks can increase the understanding of how risk factors contribute to aging at the cellular level. This study explored the association between education or lifestyle risk factors for age-related diseases and the acceleration of four DNAm clocks, including intrinsic (IEAA) and extrinsic epigenetic age acceleration (EEAA), PhenoAge acceleration (PhenoAA), and GrimAge acceleration (GrimAA) in the African American participants of the Genetic Epidemiology Network of Arteriopathy. We performed both cross-sectional and longitudinal analyses. In cross-sectional analyses, gender, education, BMI, smoking, and alcohol consumption were all independently associated with GrimAA, whereas only some of them were associated with other clocks. The effect of smoking and education on GrimAA varied by gender. Longitudinal analyses suggest that age and BMI continued to increase GrimAA, and that age and current smoking continued to increase PhenoAA after controlling DNAm clocks at baseline. In conclusion, education and common lifestyle risk factors were associated with multiple DNAm clocks. However, the association with each risk factor varied by clock, which suggests that different clocks may capture adverse effects from different environmental stimuli.
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