Evidence map›Paper›PMID 31466386›Full record

ReviewJournal of clinical medicine2019

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Strategies for In Vivo Administration: Part-II.

Raquel Vieira, Selma B Souto, Elena Sánchez-López, Ana López Machado, Patricia Severino, Sajan Jose, Antonello Santini, Amelia M Silva, Ana Fortuna, Maria Luisa García and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Foods (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Journal of diabetes and metabolic disorders · 2024
    Article
  6. Exploring the Biological Effects of Anti-Diabetic Vanadium Compounds in the Liver, Heart and Brain.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Current bioactive compounds · 2023
    Article
  11. Review
  12. Article
  13. The Evolution of Pharmacological ActivitiesPharmaceuticals (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Review
  16. Plants and Diabetes: Description, Role, Comprehension and Exploitation.International journal of molecular sciences · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Raquel VieiraDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Selma B SoutoDepartment of Endocrinology, Braga Hospital, Sete Fontes, 4710-243 São Victor Braga, Portugal.
Elena Sánchez-LópezDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Ana López MachadoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Nanoscience and Nanotechnology (IN2UB), Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
Patricia SeverinoLaboratory of Nanotechnology and Nanomedicine (LNMED), Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Sajan JoseDepartment of Pharmaceutical Sciences, Mahatma Gandhi University, Cheruvandoor Campus, Ettumanoor, Kerala 686631, India.
Antonello SantiniDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49-80131 Naples, Italy.
Amelia M SilvaDepartment of Biology and Environment, University of Trás-os Montes e Alto Douro (UTAD), Quinta de Prados, 5001-801 Vila Real, Portugal.
Ana FortunaLaboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Maria Luisa GarcíaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Nanoscience and Nanotechnology (IN2UB), Av. Joan XXIII, 27-31, 08028 Barcelona, Spain. ebsouto@ff.uc.pt.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal. ebsouto@ff.uc.pt.
University of Coimbra · PTBiomedical Research Networking Center on Neurodegenerative Diseases · ESHospital Braga · PTMahatma Gandhi University · INUniversidade Tiradentes · BRUniversitat de Barcelona · ESUniversity of Naples Federico II · ITUniversity of Trás-os-Montes and Alto Douro · PT

Funding

Fundação para a Ciência e a Tecnologia M-ERA-NET/0004/2015-PAIRED and UID/AGR/04033/2019 (CITAB)Institute of Nanoscience and Nanotechnology project ART(2018)
6 · The paper itself

Abstract

Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic β-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.

Indexed as

administration routesanimal modelsdiabetes mellitusin vivo

Identifiers

PMID31466386
PMCPMC6780268
OpenAlexW2971164055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.