Evidence map›Paper›PMID 31466351›Full record

ArticleMolecules (Basel, Switzerland)2019

The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil-DNA Glycosylase SMUG1.

Danila A Iakovlev, Irina V Alekseeva, Yury N Vorobjev, Nikita A Kuznetsov, Olga S Fedorova

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Danila A IakovlevInstitute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., Novosibirsk 630090, Russia.ORCID 0000-0002-7596-3659
Irina V AlekseevaInstitute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., Novosibirsk 630090, Russia.
Yury N VorobjevInstitute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., Novosibirsk 630090, Russia.
Nikita A KuznetsovInstitute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., Novosibirsk 630090, Russia. nikita.kuznetsov@niboch.nsc.ru.ORCID 0000-0002-4016-198X
Olga S FedorovaInstitute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., Novosibirsk 630090, Russia. fedorova@niboch.nsc.ru.ORCID 0000-0002-4001-7187
Russian Academy of Sciences · RU

Funding

Russian Science Foundation 16-14-10038Russian-State-funded budget project AAAA-A17-117020210022-4
6 · The paper itself

Abstract

Human SMUG1 (hSMUG1) hydrolyzes the

Indexed as

Amino Acid SubstitutionArginineCatalytic DomainDNADNA DamageHistidineHumansModels, MolecularMolecular Dynamics SimulationPhenylalanineProtein BindingUracil-DNA GlycosidaseArginineDNAHistidinePhenylalanineSMUG1 protein, humanUracil-DNA GlycosidaseDNA repairfluorescencehomology modelinghuman uracil–DNA glycosylasemolecular dynamics simulationmutantSMUG1stopped-flow kineticsstructure

Identifiers

PMID31466351
PMCPMC6749576
OpenAlexW2971179204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.