Evidence map›Paper›PMID 31466309›Full record

ReviewNanomaterials (Basel, Switzerland)2019

Toxicity of Zero- and One-Dimensional Carbon Nanomaterials.

Iruthayapandi Selestin Raja, Su-Jin Song, Moon Sung Kang, Yu Bin Lee, Bongju Kim, Suck Won Hong, Seung Jo Jeong, Jae-Chang Lee, Dong-Wook Han

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review of Antimicrobial Properties of Carbon Nanomaterials.International journal of molecular sciences · 2026
    Review
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  10. Synthesis of Multi-Stimuli Responsive FeMolecules (Basel, Switzerland) · 2023
    Article
  11. Antioxidant potential of nanomaterials.Turkish journal of biology = Turk biyoloji dergisi · 2023
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Iruthayapandi Selestin RajaMonocrystalline Bank Research Institute, Pusan National University, Busan 46241, Korea.
Su-Jin SongDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea.
Moon Sung KangDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea.
Yu Bin LeeDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea.
Bongju KimDental Life Science Research Institute & Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital, Seoul 03080, Korea.ORCID 0000-0001-7309-5977
Suck Won HongDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea.ORCID 0000-0001-7291-1020
Seung Jo JeongGS Medical Co., Ltd., Cheongju-si, Chungcheongbuk-do 28161, Korea.
Jae-Chang LeeBio-Based Chemistry Research Center, Korea Research Institute of Chemical Technology, Ulsan 44429, Korea. jclee@krict.re.kr.
Dong-Wook HanDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea. nanohan@pusan.ac.kr.ORCID 0000-0001-8314-1981
Pusan National University · KRKorea Research Institute of Chemical Technology · KRSeoul National University Dental Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zero (0-D) and one-dimensional (1-D) carbon nanomaterials have gained attention among researchers because they exhibit a larger surface area to volume ratio, and a smaller size. Furthermore, carbon is ubiquitously present in all living organisms. However, toxicity is a major concern while utilizing carbon nanomaterials for biomedical applications such as drug delivery, biosensing, and tissue regeneration. In the present review, we have summarized some of the recent findings of cellular and animal level toxicity studies of 0-D (carbon quantum dot, graphene quantum dot, nanodiamond, and carbon black) and 1-D (single-walled and multi-walled carbon nanotubes) carbon nanomaterials. The in vitro toxicity of carbon nanomaterials was exemplified in normal and cancer cell lines including fibroblasts, osteoblasts, macrophages, epithelial and endothelial cells of different sources. Similarly, the in vivo studies were illustrated in several animal species such as rats, mice, zebrafish, planktons and, guinea pigs, at various concentrations, route of administrations and exposure of nanoparticles. In addition, we have described the unique properties and commercial usage, as well as the similarities and differences among the nanoparticles. The aim of the current review is not only to signify the importance of studying the toxicity of 0-D and 1-D carbon nanomaterials, but also to emphasize the perspectives, future challenges and possible directions in the field.

Indexed as

biomedical applicationscarbon nanomaterialsin vitro toxicityin vivo toxicityunique properties

Identifiers

PMID31466309
PMCPMC6780407
OpenAlexW2971090581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.