Evidence map›Paper›PMID 31466233›Full record

ArticleInternational journal of molecular sciences2019

A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse.

Radovan Krejcir, Lucie Krcova, Pavlina Zatloukalova, Tomas Briza, Philip J Coates, Martin Sterba, Petr Muller, Jarmila Kralova, Pavel Martasek, Vladimir Kral and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Radovan KrejcirRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Lucie KrcovaDepartment of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic.ORCID 0000-0003-2984-3565
Pavlina ZatloukalovaRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Tomas BrizaDepartment of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Philip J CoatesRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Martin SterbaRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Petr MullerRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.ORCID 0000-0002-8404-4494
Jarmila KralovaDepartment of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic.
Pavel MartasekDepartment of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic.
Vladimir KralDepartment of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Borivoj VojtesekRegional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic. vojtesek@mou.cz.
Masaryk Memorial Cancer Institute · CZCharles University · CZ

Funding

EATRIS-CZ LM2015062, LM2015064Grantová Agentura České Republiky 17-07822SMinisterstvo Školství, Mládeže a Tělovýchovy NPS I - LO1413, NPS II - LQ1604Ministerstvo Zdravotnictví Ceské Republiky RVO-VFN 64165/2012
6 · The paper itself

Abstract

Cancer cells preferentially utilize glycolysis for ATP production even in aerobic conditions (the Warburg effect) and adapt mitochondrial processes to their specific needs. Recent studies indicate that altered mitochondrial activities in cancer represent an actionable target for therapy. We previously showed that salt 1-

Indexed as

MitophagyAMP-Activated Protein Kinase KinasesAntineoplastic AgentsCarbocyaninesCell Line, TumorHumansMitochondriaProtein KinasesQuaternary Ammonium CompoundsQuinazolinesTOR Serine-Threonine KinasesAMP-Activated Protein Kinase KinasesAntineoplastic AgentsCarbocyaninesProtein KinasesQuaternary Ammonium CompoundsQuinazolinesTOR Serine-Threonine Kinasesautophagycancer therapyglucose metabolismmitochondria

Identifiers

PMID31466233
PMCPMC6747461
OpenAlexW2970230636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.