ArticleInternational journal of molecular sciences2019
Alteration of Phenolic Composition in Lettuce (
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Hydrophyte root microbiome: a novel reservoir of plant growth-promoting bacteria for enhancing lettuce (Lactuca sativa L.) growth and nutritional quality under soilless cultivation.World journal of microbiology & biotechnology · 2026Article
- Spent Mushroom Substrate Reused as Organic Fertilizer Enhances Lettuce (Microorganisms · 2026Article
- Impact of effective micro-organisms (EM) on the yield, growth and bio-chemical properties of lettuce when applied to soil and leaves.BMC plant biology · 2024Article
- Appropriate Nitrogen form Ratio and UV-A Supplementation Increased Quality and Production in Purple Lettuce (International journal of molecular sciences · 2023Article
- Phytochemicals and Antioxidant Activities of Red Oak, Red Coral and Butterhead.Tropical life sciences research · 2023Article
- Hydrogen peroxide regulates the biosynthesis of phenolic compounds and antioxidant quality enhancement in lettuce under low nitrogen condition.Food chemistry: X · 2022Article
- Molecular Effects of Iodine-Biofortified Lettuce in Human Gastrointestinal Cancer Cells.Nutrients · 2022Article
- Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce-A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2022Review
- Dietary Polyphenols: Extraction, Identification, Bioavailability, and Role for Prevention and Treatment of Colorectal and Prostate Cancers.Molecules (Basel, Switzerland) · 2022Review
- Application of Quercetin in the Treatment of Gastrointestinal Cancers.Frontiers in pharmacology · 2022Review
- Evaluation of Phytochemical Contents and In Vitro Antioxidant, Anti-Inflammatory, and Anticancer Activities of Black Rice Leaf (Foods (Basel, Switzerland) · 2021Article
- Plant Response to Mechanically-Induced Stress: A Case Study on Specialized Metabolites of Leafy Vegetables.Plants (Basel, Switzerland) · 2021Article
- Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways.Molecules (Basel, Switzerland) · 2021Review
- Phenolic and Carotenoid Profile of Lamb's Lettuce and Improvement of the Bioactive Content by Preharvest Conditions.Foods (Basel, Switzerland) · 2021Article
- Soilless Cultivation: Dynamically Changing Chemical Properties and Physical Conditions of Organic Substrates Influence the Plant Phenotype of Lettuce.Frontiers in plant science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Consumption of vegetables rich in phenolic compounds has become a useful method to reduce the risk of developing several types of cancer. This study investigated the potential relationship between the alteration of phenolic compounds in lettuce induced by reduced nitrogen supply and its anti-proliferative effects on Caco-2 colorectal cancer cells. Our results showed that phenolic extracts from lettuce grown under low nitrogen conditions (LP) exhibited better anti-proliferative effects against Caco-2 cells, in part, by interfering with the cell cycle and inducing apoptosis, compared with those from lettuce supplied with adequate nitrogen. High performance liquid chromatography (HPLC) analysis and correlation analysis indicated that the better anticancer activity of LP may be not only related to the increased phenolic content, but also associated with the increased percentage contribution of quercetin to total phenolics. Taken together, alteration of phenolic composition by reduced nitrogen supply can be an effectively strategy for the development of healthy vegetables as anticancer products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.