Evidence map›Paper›PMID 31466214›Full record

ArticleMicroorganisms2019

Heterologous Hyaluronic Acid Production in

Antonio M V Gomes, João H C M Netto, Lucas S Carvalho, Nádia S Parachin

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 36 citations in OpenAlex.

  1. EngineeringBiomolecules · 2026
    Article
  2. Review
  3. Article
  4. Microbial Hyaluronic Acid Production: A Review.Molecules (Basel, Switzerland) · 2023
    Review
  5. Imaging ofScience advances · 2023
    Article
  6. Review
  7. Prospective bacterial and fungal sources of hyaluronic acid: A review.Computational and structural biotechnology journal · 2022
    Review
  8. Evaluation ofMicroorganisms · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Antonio M V GomesGrupo de Engenharia de Biocatalisadores, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Campus Darcy Ribeiro, Bloco K. Brasilia, Federal District 70790-900, Brazil.
João H C M NettoGrupo de Engenharia de Biocatalisadores, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Campus Darcy Ribeiro, Bloco K. Brasilia, Federal District 70790-900, Brazil.ORCID 0000-0001-5600-0219
Lucas S CarvalhoGrupo de Engenharia de Biocatalisadores, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Campus Darcy Ribeiro, Bloco K. Brasilia, Federal District 70790-900, Brazil.
Nádia S ParachinGrupo de Engenharia de Biocatalisadores, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília (UnB), Campus Darcy Ribeiro, Bloco K. Brasilia, Federal District 70790-900, Brazil. nadiasp@unb.br.ORCID 0000-0002-5392-4560
Universidade de Brasília · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 403410/2016-9Fundação de Apoio a Pesquisa do Distrito Federal 0193.001605/2017
6 · The paper itself

Abstract

Hyaluronic Acid (HA) is a biopolymer composed by the monomers Glucuronic Acid (GlcUA) and N-Acetyl Glucosamine (GlcNAc). It has a broad range of applications in the field of medicine, being marketed between USD 1000-5000/kg. Its primary sources include extraction of animal tissue and fermentation using pathogenic bacteria. However, in both cases, extensive purification protocols are required to prevent toxin contamination. In this study, aiming at creating a safe HA producing microorganism, the generally regarded as safe (GRAS) yeast

Indexed as

Hyaluronic AcidHyaluronic Acid SynthaseKluyveromyces lactisPasteurella multocidaXenopus laevis

Identifiers

PMID31466214
PMCPMC6780701
OpenAlexW2971335219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.