Evidence map›Paper›PMID 31466071›Full record

ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2020

Antidepressant-Like Effect of Bauhinia blakeana Dunn in a Neuroinflammation Model in Mice.

Maribel Herrera-Ruiz, Mayra A Santillán-Urquiza, Ofelia Romero-Cerecero, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Jaime Tortoriello

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Pharmacological and Chemical Analysis ofPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maribel Herrera-RuizCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico.
Mayra A Santillán-UrquizaCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico.
Ofelia Romero-CereceroCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico.
Alejandro ZamilpaCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico.
Enrique Jiménez-FerrerCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico.
Jaime TortorielloCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Morelos, Mexico, jtortora2@yahoo.es.
Mexican Social Security Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the antidepressant effect of Bauhinia blakeana and a standardized fraction in the forced swimming test (FST) on mice with neuroinflammation induced with lipopolysaccharides (LPS). MATERIALS AND

methodsEvaluation of the antidepressant effect of Bauhinia blakeana hydroalcoholic extract (BbHA) and its fractions was carried out in behavioral tests on mice with LPS-induced neuroinflammation.

resultsBbHA had a significant antidepressant effect, measured on healthy mice in the FST. Bio-guided chemical separation of the extract produced a methanolic fraction (BbMe), which decreased the immobility time in FST. In this test, the intraperitoneal administration of LPS induced depression in mice, and BbHA and BbMe counteracted this effect, significantly decreasing the induced depression. Quantification of inflammatory mediators (IL-10, IL-4, IL-6, IL-1β, and TNF-α) in the brain demonstrated that BbHA and BbMe effectively decreased the effect of LPS on the brain concentration of all measured cytokines.

conclusionsBauhinia blakeana produced an antidepressant effect, while BbMe also exerted a modulating effect, on the damage induced by LPS. Rutin, a glycosylated flavonoid, was identified as the main compound in the active fraction, which could mediate in the antidepressant and immunomodulatory effect.

Indexed as

AnimalsAntidepressive AgentsBauhiniaBrainCytokinesDepressionDisease Models, AnimalInflammationMaleMiceMice, Inbred ICRSwimmingAntidepressive AgentsCytokinesAntidepressantCytokinesLipopolysaccharidesMedicinal plantsMexican traditional medicineNeuroinflammationRutin

Identifiers

PMID31466071
PMCPMC7098321
OpenAlexW2976784572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.