Evidence map›Paper›PMID 31466035›Full record

ReviewCurrent opinion in chemical biology2019

Chemical tools to characterize peptidoglycan synthases.

Atsushi Taguchi, Daniel Kahne, Suzanne Walker

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Minimalist TetrazineJournal of the American Chemical Society · 2024
    Article
  2. Review
  3. Inhibition ofMicrobiology (Reading, England) · 2022
    Article
  4. Review
  5. ProtectedACS chemical biology · 2021
    Article
  6. Looks can be deceiving: Bacterial enzymes work through unanticipated mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. The LpoA activator is required to stimulate the peptidoglycan polymerase activity of its cognate cell wall synthase PBP1a.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Atsushi TaguchiDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: suzanne_walker@hms.harvard.edu.

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI BELTZ, GERALD A · 2014 to 2018
$25.2M
Mechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9M
NIAID NIH HHS U19 AI109764NIGMS NIH HHS R01 GM076710
6 · The paper itself

Abstract

The peptidoglycan cell wall is a unique macromolecular structure in bacteria that defines their shape and confers protection from the surrounding environment. Decades of research has focused on understanding the peptidoglycan synthesis pathway and exploiting its essentiality for antibiotic development. Recently, a new class of peptidoglycan polymerases known as the SEDS (shape, elongation, division and sporulation) proteins were identified; these polytopic membrane proteins function together with the better-known penicillin-binding proteins (PBPs) to build the cell wall. In this review, we will highlight recent developments in chemical tools and methods to label the bacterial cell wall and discuss how these developments are leading to a better understanding of peptidoglycan synthases and their cellular roles.

Indexed as

Enzyme AssaysMolecular ProbesPenicillin-Binding ProteinsMolecular ProbesPenicillin-Binding Proteins

Identifiers

PMID31466035
PMCPMC6926152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.