ArticleJournal of diabetes investigation2020
Consistency of plasma glucagon levels in patients with type 1 diabetes after a 1-year period.
Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Advances in glucagon research ~ 100th anniversary: invitation to the new 'glucagon-ology'.Diabetology international · 2024Review
- Newly discovered knowledge pertaining to glucagon and its clinical applications.Journal of diabetes investigation · 2023Review
- Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy.Scientific reports · 2023Article
- Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus.Journal of diabetes investigation · 2023Article
- Changes in glucagon secretion induced by food intake in fulminant type 1 diabetes mellitus: a case report.Diabetology international · 2022Article
- Protein ingestion can significantly affect glucagon secretion along with blood urea nitrogen alteration in type 1 diabetes.Journal of diabetes investigation · 2021Article
- Beginning of a new era in glucagon research: Breakthrough by the new glucagon assay.Journal of diabetes investigation · 2020Article
- Consistency of plasma glucagon levels in patients with type 1 diabetes after a 1-year period.Journal of diabetes investigation · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Recent progress in research on glucagon and α-cells highlights their pathophysiological roles in diabetes. We previously showed that plasma glucagon levels measured by newly developed enzyme-linked immunosorbent assay were dysregulated in patients with type 1 diabetes with respect to plasma glucose levels, suggesting dysregulated secretion. In the current study, the annual change in plasma glucagon levels was assessed in these same patients. We found that the plasma glucagon levels in the 66 Japanese patients involved in the study were significantly correlated between both years. In addition, they were significantly associated with serum blood urea nitrogen levels in a multivariate linear regression analysis, as reported in our previous study. The statistical correlation in glucagon levels between annual checkups and the sustained significant correlation between glucagon and blood urea nitrogen suggest a constant dysregulation of glucagon in association with altered amino acid metabolism in patients with type 1 diabetes.
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