ReviewMicrocirculation (New York, N.Y. : 1994)2020
Contrast-enhanced ultrasound for quantification of tissue perfusion in humans.
Review in Microcirculation (New York, N.Y. : 1994), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Contrast enhanced ultrasound for traumatic spinal cord injury: an overview of current and future applications.Spinal cord series and cases · 2024Pooled it
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
- Evaluation of Intracranial Pressure in Patients with Severe Brain Injury Using Contrast-Enhanced Ultrasound: A Pilot Study with Preliminary Findings.Neurocritical care · 2026Observational
- Evolving B-mode ultrasound-based techniques for assessing metabolic dysfunction-associated steatotic liver disease: Now and beyond.Liver research (Beijing, China) · 2026Review
- Sequential contrast-enhanced ultrasound assessment of intraplaque enhancement in carotid plaques.Journal of ultrasound · 2026Article
- Article
- Visualizing spinal tumors: a review of intraoperative contrast enhanced ultrasound during spinal tumor resections.Frontiers in oncology · 2026Review
- Diagnostically competitive performance of a physiology-informed generative multi-task network for contrast-free CT perfusion.Frontiers in human neuroscience · 2026Article
- Insights into canine reproductive health: ultrasonographic evaluation of the uterus-a review.Frontiers in veterinary science · 2026Review
- Detecting biliary complications following liver transplantation with contrast-enhanced ultrasound.World journal of radiology · 2025Review
- Application of ultrasound in liver cancer from 2014 to 2024: bibliometric analysis and global trends.Discover oncology · 2025Article
- Imaging of macrophage accumulation in solid tumors with ultrasound.Nature communications · 2025Article
- Harnessing chemically crosslinked microbubble clusters using deep learning for ultrasound contrast imaging.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury.Diabetology & metabolic syndrome · 2025Review
- Quantitative contrast-enhanced ultrasonography in the diagnosis and grading of hepatic steatosis in brain-dead donors.Quantitative imaging in medicine and surgery · 2025Article
- Unique model of chronic hypoxia in fetal lambs demonstrates abnormal contrast-enhanced ultrasound brain perfusion.Pediatric research · 2025Article
- Predictive Value of TRUS and CEUS Parameters for Lymph Node Metastasis in Rectal Cancer: A Retrospective Study.International journal of general medicine · 2025Article
- Overview of Wearable Healthcare Devices for Clinical Decision Support in the Prehospital Setting.Sensors (Basel, Switzerland) · 2024Review
- Characterization of Indeterminate Breast Lesions Based on Pressure Estimates by Noninvasive 3D Contrast-Enhanced Ultrasound.Ultrasound in medicine & biology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrast-enhanced ultrasound is an imaging technique that can be used to quantify microvascular blood volume and blood flow of vital organs in humans. It relies on the use of microbubble contrast agents and ultrasound-based imaging of microbubbles. Over the past decades, both ultrasound contrast agents and experimental techniques to image them have rapidly improved, as did experience among investigators and clinicians. However, these improvements have not yet resulted in uniform guidelines for CEUS when it comes to quantification of tissue perfusion in humans, preventing its uniform and widespread use in research settings. The objective of this review is to provide a methodological overview of CEUS and its development, the influences of hardware and software settings, type and dosage of ultrasound contrast agent, and method of analysis on CEUS-derived perfusion data. Furthermore, we will discuss organ-specific imaging challenges, advantages, and limitations of CEUS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.