Evidence map›Paper›PMID 31465460›Full record

ArticlePloS one2019

Application of simulation-based CYP26 SNP-environment barcodes for evaluating the occurrence of oral malignant disorders by odds ratio-based binary particle swarm optimization: A case-control study in the Taiwanese population.

Ping-Ho Chen, Li-Yeh Chuang, Kuo-Chuan Wu, Yan-Hsiung Wang, Tien-Yu Shieh, Jim Jinn-Chyuan Sheu, Hsueh-Wei Chang, Cheng-Hong Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ping-Ho ChenSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Li-Yeh ChuangDepartment of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan.
Kuo-Chuan WuDepartment of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan.
Yan-Hsiung WangSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tien-Yu ShiehGlobal Center of Excellence for Oral Health Research and Development, Kaohsiung, Taiwan.
Jim Jinn-Chyuan SheuInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
Hsueh-Wei ChangInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.ORCID 0000-0002-0357-8081
Cheng-Hong YangDepartment of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan.
National Sun Yat-sen University · TWKaohsiung Medical University · TWI-Shou University · TWNational Kaohsiung University of Science and Technology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGenetic polymorphisms and social factors (alcohol consumption, betel quid (BQ) usage, and cigarette consumption), both separately or jointly, play a crucial role in the occurrence of oral malignant disorders such as oral and pharyngeal cancers and oral potentially malignant disorders (OPMD). MATERIAL AND

methodsSimultaneous analyses of multiple single nucleotide polymorphisms (SNPs) and environmental effects on oral malignant disorders are essential to examine, albeit challenging. Thus, we conducted a case-control study (N = 576) to analyze the risk of occurrence of oral malignant disorders by using binary particle swarm optimization (BPSO) with an odds ratio (OR)-based method.

resultsWe demonstrated that a combination of SNPs (CYP26B1 rs887844 and CYP26C1 rs12256889) and socio-demographic factors (age, ethnicity, and BQ chewing), referred to as the combined effects of SNP-environment, correlated with maximal risk diversity of occurrence observed between the oral malignant disorder group and the control group. The risks were more prominent in the oral and pharyngeal cancers group (OR = 10.30; 95% confidence interval (CI) = 4.58-23.15) than in the OPMD group (OR = 5.42; 95% CI = 1.94-15.12).

conclusionsSimulation-based "SNP-environment barcodes" may be used to predict the risk of occurrence of oral malignant disorders. Applying simulation-based "SNP-environment barcodes" may provide insight into the importance of screening tests in preventing oral and pharyngeal cancers and OPMD.

Indexed as

Gene-Environment InteractionPolymorphism, Single NucleotideAdultCase-Control StudiesComputer SimulationCytochrome P450 Family 26FemaleHumansMaleMiddle AgedMouth NeoplasmsOdds RatioPharyngeal NeoplasmsRisk FactorsTaiwanCytochrome P450 Family 26

Identifiers

PMID31465460
PMCPMC6715230
OpenAlexW2971211046

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.