ArticlePLoS neglected tropical diseases2019
The Accuracy of Histopathological and Cytopathological Techniques in the Identification of the Mycetoma Causative Agents.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 57 citations in OpenAlex.
- A qPCR identification scheme to detect the most common causative agents of actinomycetoma in Africa.PLoS neglected tropical diseases · 2026Article
- A qPCR identification scheme to differentiate actinomycetoma from eumycetoma.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Mycetoma.PLoS neglected tropical diseases · 2026Review
- Optimizing a Conventional Multiplex PCR for Simultaneous Detection of Granulomatous Skin Infection Agents:Journal of tropical medicine · 2026Article
- Surgical Management and Antifungal Therapy for Extensive Eumycetoma of the Right Foot: A Case Report from Resource Limited Settings.International medical case reports journal · 2026Article
- Advanced Eumycetoma of the Right Foot Resulting in Below-Knee Amputation in Somalia: A Case Report.International medical case reports journal · 2026Article
- Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis.PLoS neglected tropical diseases · 2025Article
- Dermatologic fungal neglected tropical diseases-Part I. Epidemiology and clinical features.Journal of the American Academy of Dermatology · 2025Review
- A Longstanding Case of Black Grain Mycetoma in a Somalian Male Patient: A Case Report.Clinical case reports · 2025Article
- Eumycetoma Caused by Aspergillus terreus: A Case Report and Literature Review.The American journal of tropical medicine and hygiene · 2025Review
- Unravelling the challenges of mycetoma: a case series highlighting diagnostic dilemmas and therapeutic triumphs.Skin health and disease · 2025Article
- Comprehensive management of actinomycetoma in a young male: A case report from Somalia.IDCases · 2025Article
- A study of case management challenge for black grain eumycetoma during the ongoing war in Sudan.Clinical case reports · 2024Article
- An updated list of eumycetoma causative agents and their differences in grain formation and treatment response.Clinical microbiology reviews · 2024Review
- Reconstructive surgery for mycetoma: Preliminary algorithm and a systematic review.JPRAS open · 2024Review
- Naphthylisoquinoline alkaloids: novel agents against the causative pathogens of eumycetoma and actinomycetoma-Antimicrobial agents and chemotherapy · 2024Article
- Complete characterization of RNA biomarker fingerprints using a multi-modal ATR-FTIR and SERS approach for label-free early breast cancer diagnosis.RSC advances · 2024Article
- Recurrent abdominal wall mass in a hepatitis B-positive male: An unusual case of lumbar mycetoma.Clinical case reports · 2023Article
- Unusual manifestation of cystic mycetoma lesions: A case report.Clinical case reports · 2023Article
- The First Case ofJournal of fungi (Basel, Switzerland) · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycetoma is a devastating neglected tropical disease, caused by various fungal and bacterial pathogens. Correct diagnosis to the species level is mandatory for proper treatment. In endemic areas, various diagnostic tests and techniques are in use to achieve that, and that includes grain culture, surgical biopsy histopathological examination, fine needle aspiration cytological (FNAC) examination and in certain centres molecular diagnosis such as PCR. In this retrospective study, the sensitivity, specificity and diagnostic accuracy of grain culture, surgical biopsy histopathological examination and FNAC to identify the mycetoma causative organisms were determined. The histopathological examination appeared to have better sensitivity and specificity. The histological examination results were correct in 714 (97.5%) out of 750 patients infected with Madurella mycetomatis, in 133 (93.6%) out of 142 patients infected with Streptomyces somaliensis, in 53 (74.6%) out of 71 patients infected with Actinomadura madurae and in 12 (75%) out of 16 patients infected with Actinomadura pelletierii. FNAC results were correct in 604 (80.5%) out of 750 patients with Madurella mycetomatis eumycetoma, in 50 (37.5%) out of 133 Streptomyces somaliensis patients, 43 (60.5%) out of 71 Actinomadura madurae patients and 11 (68.7%) out of 16 Actinomadura pelletierii. The mean time required to obtain the FNAC result was one day, and for the histopathological examinations results it was 3.5 days, and for grain it was a mean of 16 days. In conclusion, histopathological examination and FNAC are more practical techniques for rapid species identification than grain culture in many endemic regions.
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