ArticlePLoS genetics2019
BZU2/ZmMUTE controls symmetrical division of guard mother cell and specifies neighbor cell fate in maize.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 94 citations in OpenAlex.
- Force-responsive symmetric cell divisions orient stomata along global tissue axes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution.The Plant cell · 2026Article
- Better together: the transcription factor MUTE aggregates into nuclear condensates to regulate stomatal development in maize.The Plant cell · 2026Article
- Genetic encoding of climate-responsive stomatal developmental plasticity in tomato.bioRxiv : the preprint server for biology · 2026Article
- MUTE drives asymmetric divisions to form stomatal subsidiary cells in Crassulaceae succulents.Science advances · 2026Article
- Regulation of stomatal development by receptor-like kinases and receptor-like proteins inFrontiers in plant science · 2026Review
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- Do grasses have meristemoids?The New phytologist · 2025Article
- Guardians of Water and Gas Exchange: Adaptive Dynamics of Stomatal Development and Patterning.Plants (Basel, Switzerland) · 2025Review
- How meristems shape plant architecture in cereals-Cereal Stem Cell Systems (CSCS) Consortium.The Plant cell · 2025Review
- DSD1/ZmICEb regulates stomatal development and drought tolerance in maize.Journal of integrative plant biology · 2025Article
- Leaf Size Determines Damage- and Herbivore-Induced Volatile Emissions in Maize.Plant, cell & environment · 2025Article
- A CRY1-HY5-MYB signaling cascade fine-tunes guard cell reactive oxygen species levels and triggers stomatal opening.The Plant cell · 2025Article
- Stomatal development in the changing climate.Development (Cambridge, England) · 2024Review
- Dual role of BdMUTE during stomatal development in the model grass Brachypodium distachyon.Development (Cambridge, England) · 2024Article
- Molecular Mechanisms for Regulating Stomatal Formation across Diverse Plant Species.International journal of molecular sciences · 2024Review
- Architecture and functions of stomatal cell walls in eudicots and grasses.Annals of botany · 2024Review
- Regulation of stomatal development by epidermal, subepidermal and long-distance signals.Plant molecular biology · 2024Review
- Article
- Cell wall anisotropy plays a key role in Zea mays stomatal complex movement: the possible role of the cell wall matrix.Plant molecular biology · 2023Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intercellular communication in adjacent cell layers determines cell fate and polarity, thus orchestrating tissue specification and differentiation. Here we use the maize stomatal apparatus as a model to investigate cell fate determination. Mutations in ZmBZU2 (bizui2, bzu2) confer a complete absence of subsidiary cells (SCs) and normal guard cells (GCs), leading to failure of formation of mature stomatal complexes. Nuclear polarization and actin accumulation at the interface between subsidiary mother cells (SMCs) and guard mother cells (GMCs), an essential pre-requisite for asymmetric cell division, did not occur in Zmbzu2 mutants. ZmBZU2 encodes a basic helix-loop-helix (bHLH) transcription factor, which is an ortholog of AtMUTE in Arabidopsis (BZU2/ZmMUTE). We found that a number of genes implicated in stomatal development are transcriptionally regulated by BZU2/ZmMUTE. In particular, BZU2/ZmMUTE directly binds to the promoters of PAN1 and PAN2, two early regulators of protodermal cell fate and SMC polarization, consistent with the low levels of transcription of these genes observed in bzu2-1 mutants. BZU2/ZmMUTE has the cell-to-cell mobility characteristic similar to that of BdMUTE in Brachypodium distachyon. Unexpectedly, BZU2/ZmMUTE is expressed in GMC from the asymmetric division stage to the GMC division stage, and especially in the SMC establishment stage. Taken together, these data imply that BZU2/ZmMUTE is required for early events in SMC polarization and differentiation as well as for the last symmetrical division of GMCs to produce the two GCs, and is a master determinant of the cell fate of its neighbors through cell-to-cell communication.
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