ArticleOptics letters2019
Noninvasive, in vivo rodent brain optical coherence tomography at 2.1 microns.
Article in Optics letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Broadband 2-µm fiber-laser supercontinuum for high-resolution optical coherence tomography.Biomedical optics express · 2026Article
- Spectral dependence of lipofuscin fluorescence lifetimes revealed by FLIM with a superconducting nanowire single-photon detector.Journal of biomedical optics · 2026Article
- Review of shortwave infrared imaging and spectroscopy in tissue [Invited].Biomedical optics express · 2025Review
- Diffuse reflectance spectroscopy of the cartilage tissue in the fourth optical window.Biomedical optics express · 2023Article
- ImprovedJournal of biomedical optics · 2023Article
- Review on Laser Technology in Intravascular Imaging and Treatment.Aging and disease · 2022Review
- 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain.Light, science & applications · 2021Article
- Longitudinal in-vivo OCM imaging of glioblastoma development in the mouse brain.Biomedical optics express · 2020Article
- Compact and contactless reflectance confocal microscope for neurosurgery.Biomedical optics express · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In biological tissue, longer near-infrared wavelengths generally experience less scattering and more water absorption. Here we demonstrate an optical coherence tomography (OCT) system centered at 2.1 microns, whose bandwidth falls in the 2.2 micron water absorption optical window, for in vivo imaging of the rodent brain. We show in vivo that at 2.1 microns, the OCT signal is actually attenuated less in cranial bone than at 1.3 microns, and is also less susceptible to multiple scattering tails. We also show that the 2.2 micron window enables direct spectroscopic OCT assessment of tissue water content. We conclude that with further optimization, 2.2 micron OCT will have advantages in low-water-content tissue such as bone, as well as applications where extensive averaging is possible to compensate absorption losses.
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Registered trials
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