ArticleMicrobiome2019
A new family of uncultivated bacteria involved in methanogenesis from the ubiquitous osmolyte glycine betaine in coastal saltmarsh sediments.
Article in Microbiome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Viral lysis and host reprogramming impact carbohydrate, amino acid, and osmolyte cycling in salt-marsh tidal creek sediments.ISME communications · 2026Article
- Methane cycling microorganisms drive seasonal variation of methane emission in mangrove ecosystems.Environmental microbiome · 2025Article
- Coastal methane emissions driven by aerotolerant methanogens using seaweed and seagrass metabolites.Nature geoscience · 2025Article
- Methylotrophy in the Mire: direct and indirect routes for methane production in thawing permafrost.mSystems · 2024Article
- Modulation of gut microbiota by foods and herbs to prevent cardiovascular diseases.Journal of traditional and complementary medicine · 2023Review
- Methanogen activity and microbial diversity in Gulf of Cádiz mud volcano sediments.Frontiers in microbiology · 2023Article
- Glycine betaine uptake and metabolism in marine microbial communities.Environmental microbiology · 2022Article
- Diverse methylotrophic methanogenic archaea cause high methane emissions from seagrass meadows.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phosphorus stress induces the synthesis of novel glycolipids in Pseudomonas aeruginosa that confer protection against a last-resort antibiotic.The ISME journal · 2021Article
- Bacteria and Archaea Synergistically Convert Glycine Betaine to Biogenic Methane in the Formosa Cold Seep of the South China Sea.mSystems · 2021Article
- Aerobic bacterial methane synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Diversity, metabolism and cultivation of archaea in mangrove ecosystems.Marine life science & technology · 2021Review
- Article
- Structure and function of the Arctic and Antarctic marine microbiota as revealed by metagenomics.Microbiome · 2020Article
- Betaine Modulates Rumen Archaeal Community and Functioning during Heat and Osmotic Stress ConditionsArchaea (Vancouver, B.C.) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoastal environments are dynamic and rapidly changing. Living organisms in coastal environments are known to synthesise large quantities of organic osmolytes, which they use to cope with osmotic stresses. The organic osmolyte glycine betaine (GBT) is ubiquitously found in marine biota from prokaryotic Bacteria and Archaea to coastal plants, marine protozoa, and mammals. In intertidal coastal sediment, GBT represents an important precursor of natural methane emissions and as much as 90% of total methane production in these ecosystems can be originated from methanogenesis from GBT and its intermediate trimethylamine through microbial metabolism.
resultsWe set out to uncover the microorganisms responsible for methanogenesis from GBT using stable isotope labelling and metagenomics. This led to the recovery of a near-complete genome (2.3 Mbp) of a novel clostridial bacterium involved in anaerobic GBT degradation. Phylogenetic analyses of 16S rRNA gene, functional marker genes, and comparative genomics analyses all support the establishment of a novel family Candidatus 'Betainaceae' fam. nov. in Clostridiales and its role in GBT metabolism.
conclusionsOur comparative genomes and metagenomics analyses suggest that this bacterium is widely distributed in coastal salt marshes, marine sediments, and deep subsurface sediments, suggesting a key role of anaerobic GBT metabolism by this clostridial bacterium in these ecosystems.
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