Evidence map›Paper›PMID 31464628›Full record

ArticleNutrition journal2019

Iron-related dietary pattern increases the risk of poor cognition.

Zumin Shi, Tahra El-Obeid, Ming Li, Xiaoyue Xu, Jianghong Liu

Abstract read
In one paragraph

Article in Nutrition journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zumin ShiHuman Nutrition Department, College of Health Science, QU Health, Qatar University, Doha, Qatar. zumin@qu.edu.qa.ORCID 0000-0002-3099-3299
Tahra El-ObeidHuman Nutrition Department, College of Health Science, QU Health, Qatar University, Doha, Qatar.
Ming LiCentre for Population Health Research, Division of Health Sciences, University of South Australia, Adelaide, Australia.
Xiaoyue XuFaculty of Health, University of Technology Sydney, Sydney, Australia.
Jianghong LiuUniversity of Pennsylvania School of Nursing, Philadelphia, USA.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
MONITORING SOCIAL CHANGE: HEALTH, REPRODUCTION, AGINGR01HD030880 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S, POPKIN, BARRY M · 1994 to 2024
$27.0M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGER01HD038700 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2000 to 2004
$1.5M
Nutrition-Related NCD Prevention Training in ChinaD43TW009077 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2011 to 2015
$1.1M
Nutrition-Related NCD Prevention Training in ChinaD43TW007709 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2006 to 2010
$723k
FIC NIH HHS D43 TW007709FIC NIH HHS D43 TW009077NICHD NIH HHS R01 HD030880NICHD NIH HHS R01 HD038700NICHD NIH HHS R24 HD050924NICHD NIH HHS T32 HD007168NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

introductionHigh iron intake has been shown to be associated with poor cognition. We aimed to examine the association between iron-related dietary pattern (IDP) and cognitive function in Chinese adults.

methodLongitudinal study data from the China Health and Nutrition Survey (CHNS) during 1991-2006 were used (N = 4852, ≥55 years old). Dietary intake was obtained from a 3-day food record during home visits. Reduced rank regression was used to construct IDP with iron intake as a response variable. Cognitive function was assessed in 1997, 2000, 2004 and 2006. Multivariable mixed linear regression and logistic regression were used in the analyses.

resultsIDP was characterised by high intake of fresh vegetable, wheat, legume, beverage, offal, rice and whole grain. High IDP intake was associated with poor cognition. In fully adjusted models, across the quartiles of IDP, the odds ratio (95% CI) for poor cognitive function were: 1.00, 1.06 (0.86-1.30), 1.24 (0.99-1.54), and 1.50 (1.17-1.93), respectively. There was a borderline significant interaction between IDP and meat intake (p interaction 0.085). The association between high IDP and poor cognition was only observed among those with no or low intake of meat. With the adjustment of carbohydrate or iron intake, the IDP and cognition association became non-significant. IDP was positively associated with lead intake. The association between IDP and poor cognition was partly mediated by lead intake.

conclusionsIron-related dietary pattern is associated with poor cognition in Chinese adults, partly due to high intake of carbohydrate, iron and lead.

Indexed as

Nutritional StatusAgedChinaCognition DisordersDietDiet RecordsFemaleHumansIron, DietaryLongitudinal StudiesMaleMiddle AgedNutrition SurveysIron, DietaryAdultsChineseCognitive functionDietary patternLead intake

Identifiers

PMID31464628
PMCPMC6716885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.