Evidence map›Paper›PMID 31464579›Full record

ReviewThe journal of headache and pain2019

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing.

Andrea M Harriott, Lauren C Strother, Marta Vila-Pueyo, Philip R Holland

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Mechanosensitive receptors in migraine: a systematic review.The journal of headache and pain · 2024
    Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Chronification of migraine sensitizes to CGRP in male and female mice.Cephalalgia : an international journal of headache · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrea M HarriottNeurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Lauren C StrotherHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Marta Vila-PueyoHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Philip R HollandHeadache Group, Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK. Philip.holland@kcl.ac.uk.ORCID http://orcid.org/0000-0003-3345-4853

Funding

European Research Council 602633Medical Research Council G0802760Medical Research Council G1001253Medical Research Council G108/638Medical Research Council MR/P006264/1Medical Research Council MR/S01165X/1The Dunhill Medical Trust R605/0717The International Headache Society N/AThe Migraine Trust N/AWellcome Trust 104033
6 · The paper itself

Abstract

backgroundMigraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. MAIN BODY: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes.

conclusionSeveral well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.

Indexed as

Migraine DisordersModels, AnimalAnimalsHumansAnimal modelsElectrophysiologyHeadacheMigrainePainPreclinicalTranslation

Identifiers

PMID31464579
PMCPMC6734323

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.