ArticleHuman brain mapping2019
Enhancement of indirect functional connections with shortest path length in the adult autistic brain.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- Quantifying Similarity of Dynamic Brain Networks: Two Novel Indices for Structural Change and Temporal Evolution.Bioengineering (Basel, Switzerland) · 2025Article
- Improving brain difference identification in autism spectrum disorder through enhanced head motion correction in ICA-AROMA.Communications biology · 2025Article
- Language networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies.Review journal of autism and developmental disorders · 2025Article
- Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Decreasing distance from tumor to the language network causes language deficit.Human brain mapping · 2023Article
- Identification of methylation markers for diagnosis of autism spectrum disorder.Metabolic brain disease · 2022Article
- Exploration of sleep function connection and classification strategies based on sub-period sleep stages.Frontiers in neuroscience · 2022Article
- Quantitative Identification of Functional Connectivity Disturbances in Neuropsychiatric Lupus Based on Resting-State fMRI: A Robust Machine Learning Approach.Brain sciences · 2020Article
- Enhancement of indirect functional connections with shortest path length in the adult autistic brain.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 6 countries.
Funding
Abstract
Autism is a neurodevelopmental condition characterized by atypical brain functional organization. Here we investigated the intrinsic indirect (semi-metric) connectivity of the functional connectome associated with autism. Resting-state functional magnetic resonance imaging scans were acquired from 65 neurotypical adults (33 males/32 females) and 61 autistic adults (30 males/31 females). From functional connectivity networks, semi-metric percentages (SMPs) were calculated to assess the proportion of indirect shortest functional pathways at global, hemisphere, network, and node levels. Group comparisons were then conducted to ascertain differences between autism and neurotypical control groups. Finally, the strength and length of edges were examined to explore the patterns of semi-metric connections associated with autism. Compared with neurotypical controls, autistic adults displayed significantly higher SMP at all spatial scales, similar to prior observations in adolescents. Differences were primarily in weaker, longer-distance edges in the majority between networks. However, no significant diagnosis-by-sex interaction effects were observed on global SMP. These findings suggest increased indirect functional connectivity in the autistic brain is persistent from adolescence to adulthood and is indicative of reduced functional network integration.
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