ArticleLasers in medical science2020
Could we diagnose childhood asthma by LIBS technique?
Article in Lasers in medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Association Between Circulating Zinc and Risk for Childhood Asthma and Wheezing: A Meta-analysis on 21 Articles and 2205 Children.Biological trace element research · 2024Pooled it
- Exposure to Heavy Metals and Allergic Outcomes in Children: a Systematic Review and Meta-analysis.Biological trace element research · 2022Pooled it
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Using LIBS as a diagnostic tool in pediatrics beta-thalassemia.Lasers in medical science · 2021Article
- Evaluation of blood and tooth element status in asthma cases: a preliminary case-control study.BMC pulmonary medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma affects children related to trace elements. Our aim was to investigate the levels of trace elements using laser-induced breakdown spectroscopy (LIBS). The study included 120 children aged 4-12 years from both sexes. They were divided into three groups: Group 1 of 40 children was diagnosed as cases of controlled asthma. Group 2 consisted of 40 children diagnosed as cases of uncontrolled asthma. Group 3 consisted of 40 children as normal control. Asthmatic children were classified according to GINA 2015. They were analyzed for serum levels of total IgE, eosinophil count, and trace metals (Zn, Cu, Pb, Mg, and Fe) by using LIBS. There was significant decrease in serum levels of Zn, Mg and Fe in children with asthma than in normal children. There was a significant decrease in uncontrolled asthmatic children than in controlled asthmatic children. But the Cu and Pb concentration in children with asthma was significantly higher than that in normal children, and there was a significant increase in uncontrolled asthmatic children than in controlled asthmatic children. Furthermore, we examined the peak flow meter, eosinophil count, and total IgE and found that the peak flow metric study had shown a significant difference in controlled cases, total eosinophil count, and IgE; the difference was more significant in the uncontrolled group than in the controlled group, and the total levels were higher in the uncontrolled group. Asthma is a common pediatric disease that is related to deficiency of Fe, Zn, and Mg and occurs with increased Pb and Cu. LIBS is a safe and rapid technique that helps in detecting asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.