Evidence map›Paper›PMID 31463801›Full record

Trial reportObesity surgery2020

Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery-a Prospective Clinical Study.

Janelle D Vaughns, Victoria C Ziesenitz, Elaine F Williams, Evan P Nadler, Gerd Mikus, Johannes van den Anker

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Janelle D VaughnsDivision of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. jvaughns@childrensnational.org.ORCID 0000-0002-2237-5829
Victoria C ZiesenitzDivision of Pediatric Pharmacology & Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
Elaine F WilliamsDivision of Pediatric Clinical Pharmacology, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Evan P NadlerDivision of Surgery, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington DC, USA.
Gerd MikusDepartment of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.
Johannes van den AnkerDivision of Pediatric Clinical Pharmacology, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Children's National · USHeidelberg University · DEUniversity of Basel · CH

Funding

Postdoctoral training in Pediatric Clinical PharmacologyT32HD087969 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VAN DEN ANKER, JOHANNES NICOLAAS · 2016 to 2020
$998k
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5T32HD087969NICHD NIH HHS T32 HD087969
6 · The paper itself

Abstract

introductionSevere obesity predisposes youth to a higher risk of venous thromboembolism (VTE). This study evaluates a BMI-stratified prophylactic dosing regimen of enoxaparin in adolescents with severe obesity undergoing surgery.

methodsAdolescents aged 12-20 years received prophylactic enoxaparin at 40 mg SC (for a BMI < 50 kg/m

resultsTen female and two male obese adolescents (age range 14-19 years) had a mean BMI of 49.9 kg/m

conclusionsOur dosing scheme of 40 mg vs. 60 mg enoxaparin stratified according to BMI proved to be effective in reaching prophylactic anti-FXa activity in 83% of adolescent patients.

Indexed as

Bariatric SurgeryAdolescentAdultAnticoagulantsChemopreventionChildDose-Response Relationship, DrugDrug Administration ScheduleEnoxaparinFemaleHumansMaleObesity, MorbidPediatric ObesityPostoperative ComplicationsPreoperative CareAnticoagulantsEnoxaparinAdolescentsBariatric surgeryEnoxaparinLMWHObesityVTE prophylaxis

Identifiers

PMID31463801
PMCPMC7375856
OpenAlexW2970400610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.