Evidence map›Paper›PMID 31463668›Full record

ArticleDigestive diseases and sciences2020

Long-Term Outcomes of Endoscopic Papillectomy for Ampullary Adenomas.

Nadav Sahar, Rajesh Krishnamoorthi, Richard A Kozarek, Michael Gluck, Michael Larsen, Andrew S Ross, Shayan Irani

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  5. Observational
  6. Article
  7. Article
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  11. Review
  12. Updates on the Management of Ampullary Neoplastic Lesions.Diagnostics (Basel, Switzerland) · 2023
    Review
  13. Clinical outcomes: endoscopic resection of duodenal ampullary lesions.Translational gastroenterology and hepatology · 2023
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nadav SaharDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA. nadav.sahar@gmail.com.ORCID 0000-0001-9347-2258
Rajesh KrishnamoorthiDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Richard A KozarekDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Michael GluckDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Michael LarsenDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Andrew S RossDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Shayan IraniDigestive Disease Institute, Virginia Mason Medical Center, 1100 9th Ave, Seattle, WA, 98101, USA.
Virginia Mason Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic papillectomy is a safe and effective treatment for ampullary adenomas and has mostly replaced surgical local resection. Recent data have discussed the role of endoscopic removal of laterally spreading adenomas associated with ampullary adenomas. We evaluated our long-term results of endoscopic papillectomy for ampullary adenomas.

methodsWe retrospectively analyzed patients who underwent endoscopic papillectomy of biopsy-proven adenomas at our tertiary center between 1994 and 2017. Clinical success was defined as complete excision of an adenoma with no evidence of recurrence during follow-up, no evidence of cancer, and without the need for surgery.

resultsA total of 161 patients (73M/88F) with a mean age of 61 (range 19-93) were included. Mean adenoma size was 20 mm (range 5-70). In total, 114/161 patients continued endoscopic surveillance for a minimum of 6 months with a median follow-up of 30 months (range 6-283). Recurrent adenomas were diagnosed in 8 patients (7%) after a median of 36 months (range 12-138). Clinical success was 83%; 35 laterally spreading adenomas were treated, which were larger than adenomas confined to the papilla (mean size 38 mm vs 15 mm, P < 0.05) and required more piecemeal resections (77% vs 15%, P < 0.05). However, no difference was found in recurrence rates between the two groups (8% vs 4%, P = 0.26); 24/161 (15%) of patients had adverse events including bleeding (6%) and pancreatitis (7%).

conclusionsEndoscopic papillectomy is a safe and effective treatment for ampullary adenomas, including laterally spreading ones. Long-term surveillance demonstrates low recurrence rates at expert centers.

Indexed as

Sphincterotomy, EndoscopicAdenomaAdultAgedAged, 80 and overAmpulla of VaterDigestive System NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalPostoperative ComplicationsRetrospective StudiesRisk FactorsTime FactorsAdenomaERCPPapillectomy

Identifiers

PMID31463668
OpenAlexW2971311951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.