Evidence map›Paper›PMID 31463641›Full record

ArticleMolecular biology reports2019

An assessment of the relationship between the expression of CCR7/CCL19 axis and selected regulatory miRNAs in non-small cell lung cancer.

Kamila Baran, Justyna Kiszałkiewicz, Monika Migdalska-Sęk, Sławomir Jabłoński, Jacek Kordiak, Adam Antczak, Katarzyna Góralska, Ewa Brzeziańska-Lasota

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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kamila BaranDepartment of Biomedicine and Genetics, Chair of Biology and Medical Parasitology, Medical University of Lodz, Lodz, Poland. kamila.baran@umed.lodz.pl.ORCID http://orcid.org/0000-0002-0029-9706
Justyna KiszałkiewiczDepartment of Biomedicine and Genetics, Chair of Biology and Medical Parasitology, Medical University of Lodz, Lodz, Poland.
Monika Migdalska-SękDepartment of Biomedicine and Genetics, Chair of Biology and Medical Parasitology, Medical University of Lodz, Lodz, Poland.
Sławomir JabłońskiDepartment of Thoracic, General and Oncological Surgery, Medical University of Lodz, Lodz, Poland.
Jacek KordiakDepartment of Thoracic, General and Oncological Surgery, Medical University of Lodz, Lodz, Poland.
Adam AntczakDepartment of General and Oncological Pulmonology, First Chair of Internal Diseases, Medical University of Lodz, Lodz, Poland.
Katarzyna GóralskaDepartment of Biomedicine and Genetics, Chair of Biology and Medical Parasitology, Medical University of Lodz, Lodz, Poland.
Ewa Brzeziańska-LasotaDepartment of Biomedicine and Genetics, Chair of Biology and Medical Parasitology, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PL

Funding

Uniwersytet Medyczny w Lodzi 503/1-013-02/503-11-003
6 · The paper itself

Abstract

CC chemokine receptor type 7 (CCR7) and its ligands has been implicated in the occurrence and progression of NSCLC. Previous studies have revealed that the diagnostic value of CCR7/CCL19 axis in lung tumorigenesis remains controversial. The present study evaluates the relationship between the mRNA expression of CCR7/CCL19 axis and selected regulatory miRNAs in NSCLC patients. It analyzes the expression level of CCR7 mRNA and its ligand in tumor tissue in relation to expression level of two miRNAs: miR let-7a and miR-335, as transcriptional regulators of study genes. Twenty-seven patients (n = 27) were enrolled. The expression of the studied genes and miRNAs was evaluated by qPCR. Tumour tissue fragments, adjacent macroscopically-unchanged lung tissue (control) and patient serum were used as biological material for study. Elevated expression of CCR7 and CCL19 mRNA was observed in patients with metastasis to lymph nodes. We noticed upregulated miR-335 expression and downregulated miR let-7a expression in patient serum with regard to AJCC tumor staging. Higher miR-335 expression and lower miR let-7a expression level was observed in patients with metastasis to lymph node. The presence of changes observed in the expression level of miR-335 and miR let-7a in the serum of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression; however, this observation requires further investigation.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungChemokine CCL19FemaleHumansLung NeoplasmsLymphatic MetastasisLymph NodesMaleMicroRNAsMiddle AgedReceptors, CCR7RNA, MessengerTranscriptomeBiomarkers, TumorCCL19 protein, humanCCR7 protein, humanChemokine CCL19MicroRNAsMIRN335 microRNA, humanmirnlet7 microRNA, humanReceptors, CCR7RNA, MessengerCCL19CCR7Lymph node metastasismiRNAsNon-small cell lung cancerReal-time polymerase chain reaction

Identifiers

PMID31463641
OpenAlexW2970499542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.