Evidence map›Paper›PMID 31463594›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2019

Somatostatin receptor imaging by SPECT and PET in patients with chronic inflammatory disorders: a systematic review.

Luz Kelly Anzola, Andor W J M Glaudemans, Rudi A J O Dierckx, F Andres Martinez, Sergio Moreno, Alberto Signore

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Protective Role of Octreotide in Acute and Chronic Lung Injuries.International journal of preventive medicine · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Incidental Visualization of Gallbladder on Post-therapy [World journal of nuclear medicine · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  12. Reference myocardial uptake values on somatostatin receptor-targeted PET: not yet in preference to visual assessment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Incidental Muscle Uptake ofNuclear medicine and molecular imaging · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Luz Kelly AnzolaNuclear Medicine Unit, Clinica Reina Sofia, Bogotà, Colombia. lkanzola@gmail.com.ORCID http://orcid.org/0000-0002-4725-1718
Andor W J M GlaudemansMedical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rudi A J O DierckxMedical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
F Andres MartinezRadiology Department Clinica Reina Sofia, Bogotà, Colombia.
Sergio MorenoClinical Epidemiologist Universidad Nacional de Colombia, Bogota, Colombia.
Alberto SignoreMedical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review the literature on the clinical application of radiolabeled somatostatin receptor scintigraphy (SRS) by SPECT and PET in adults with chronic inflammatory diseases. RESEARCH

designSystematic review of published observational studies between 1993 and 2017. DATA COLLECTION AND ANALYSIS: The Cochrane Central Register of Controlled Trials, MedLine, EMBASE, PubMed, Google Scholar, OVID, EBSCO, Scopus, and Web of Science were used to search for studies on the use of SRS in adults with chronic inflammatory diseases. A team of reviewers independently screened for eligible studies. Quality of evidence was assessed by QUADAS approach.

resultsEligible papers included 38 studies. Studied populations were heterogeneous, and patients were classified according to the diagnosed disease: endothelial inflammation, rheumatoid arthritis, cardiac allograft rejection, granulomatous diseases, small vessel vasculitis, idiopathic pulmonary fibrosis, sarcoidosis, and thyroid exophthalmopathy. Because of many quality differences between studies, it was not possible to pool data, and a narrative synthesis is reported.

conclusionResults highlight the value of SRS to detect active inflammation in several chronic inflammatory conditions, despite the bias related to the index test, showing lack of standardization of the scintigraphic technique and high variability of methods used to clinically evaluate inflammatory condition.

Indexed as

Chronic DiseaseHumansInflammationPositron-Emission TomographyReceptors, SomatostatinTomography, Emission-Computed, Single-PhotonReceptors, SomatostatinInflammatory diseasesPETSomatostatin receptor imagingSPECT

Identifiers

PMID31463594
PMCPMC6813755
OpenAlexW2970901816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.