Evidence map›Paper›PMID 31463553›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2020

Comparable clinical and functional outcomes after anterior cruciate ligament reconstruction over and under 40 years of age.

Katia Corona, M Ronga, B J Morris, J Tamini, G Zappalà, M Cherubino, S Cerciello

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Which patients need anterior cruciate ligament reconstruction after initial treatment with rehabilitation? A scoping review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Article
  4. Article
  5. Impact of age on clinical outcomes in anterior cruciate ligament reconstruction.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Second-look arthroscopy after double-bundle posterior cruciate ligament reconstruction: Effect of patient age.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katia CoronaDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Giovanni Paolo II, 86100, Campobasso, Italy. katiacorona@tiscali.it.ORCID http://orcid.org/0000-0002-7894-1789
M RongaDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via Giovanni Paolo II, 86100, Campobasso, Italy.
B J MorrisSports Medicine Center, The Shoulder Center of Kentucky, Lexington, USA.
J Tamini1a Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy.
G ZappalàASST Papa Giovanni XXIII, Bergamo, Italy.
M CherubinoDepartment of Biotechnology and Lyfe Sciences (DBSV), University of Insubria, Varese, Italy.
S CercielloCasa di Cura Villa Betania, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the present meta-analysis was to update the literature on the outcomes and complications of ACL reconstruction in patients aged 40 years and older. It has been hypothesized that patients older than 40 years of age may have comparable clinical outcomes to those of younger patients.

methodsA systematic review of articles from 1996 to 2018 was completed using Pubmed, Medline, Cochrane Reviews, and Google Scholar databases using the keyword terms "anterior cruciate ligament reconstruction" and "middle-aged OR elderly OR over 40 OR age factors." Functional and clinical outcomes (International Knee Documentation Committee, Lysholm and Tegner score and KT-1000 arthrometer), complication and graft failure rate were evaluated.

resultsEleven articles met inclusion criteria. In total, 306 middle-aged patients and 566 younger patients were included in this study. The mean age of patients > 40 was 49 ± 7 (range 40-75) years with a mean follow-up of 25 ± 9 months (range 12-68). The mean age of younger patients was 26 ± 2.7 (range 15-39) years with a mean post-operative follow-up of 26.7 ± 11.5 months (range 3-64). The results were slightly higher (but no significantly different) towards the younger group in terms of objective IKDC (P = n.s.), Lysholm (P = n.s.) and Tegner (P = n.s.) scores and knee laxity assessment (P = n.s.). Complication rate (P = n.s.) and graft failure (P = n.s.) were low even in this cohort.

conclusionsThe present meta-analysis shows that patients older than 40 years achieve comparable clinical outcomes to those of younger patients following primary ACL reconstruction. This evidence may push the surgeons toward a more aggressive approach in this specific cohort of patients. LEVEL OF EVIDENCE: III.

Indexed as

Anterior Cruciate Ligament ReconstructionTreatment OutcomeAdolescentAdultAgedAge FactorsAnterior Cruciate Ligament InjuriesFemaleHumansJoint InstabilityKneeKnee InjuriesKnee JointLysholm Knee ScoreMaleMiddle AgedAnterior cruciate ligament reconstructionMeta-analysisMiddle-aged patientsOver 40 years of aged

Identifiers

PMID31463553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.