ArticleExperimental brain research2019
Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette's syndrome.
Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Non-invasive brain stimulation as therapy: systematic review and recommendations with a focus on the treatment of Tourette syndrome.Experimental brain research · 2022Pooled it
- Developmental delay in attaining adult levels of motor excitability in children and adolescents with Tourette syndrome: a mega-analysis study.bioRxiv : the preprint server for biology · 2026Article
- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Transcranial Brain Stimulation for Neurodevelopmental Disorders : Neuromodulation and Neurodevelopmental Disorders.Galen medical journal · 2025Review
- A critical role of action-related functional networks in Gilles de la Tourette syndrome.Nature communications · 2024Article
- Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Tourette syndrome: clinical features, pathophysiology, and treatment.The Lancet. Neurology · 2023Review
- Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature.Current neurology and neuroscience reports · 2022Review
- Electrophysiology Echoes Brain Dynamics in Children and Adolescents With Tourette Syndrome-A Developmental Perspective.Frontiers in neurology · 2021Review
- Correlation between premonitory urges and tic symptoms in a Chinese population with tic disorders.Pediatric investigation · 2020Article
- Non-invasive Brain Stimulation for the Treatment of Gilles de la Tourette Syndrome.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tourette syndrome is a neurodevelopmental disorder characterised by motor and phonic tics. For some, tics can be managed using medication and/or forms of behavioural therapy; however, adverse side effects and access to specialist resources can be barriers to treatment. In this sham-controlled brain stimulation study, we investigated the effects of transcranial direct current stimulation (tDCS) on the occurrence of tics and motor cortical excitability in individuals aged 16-33 years with Tourette syndrome. Changes in tics were measured using video recordings scored using the RUSH method (Goetz et al. in Mov Disord 14:502-506, 1999) and changes in cortical excitability were measured using single-pulse transcranial magnetic stimulation (spTMS) over the primary motor cortex (M1). Video recordings and spTMS measures were taken before and after 20 min of sham or active tDCS: during which cathodal current was delivered to an electrode placed above the supplementary motor area (SMA). Tic impairment scores, calculated from the video data, were significantly lower post-cathodal stimulation in comparison with post-sham stimulation; however, the interaction between time (pre/post) and stimulation (cathodal/sham) was not significant. There was no indication of a statistically significant change in M1 cortical excitability following SMA stimulation. This study presents tentative evidence that tDCS may be helpful in reducing tics for some individuals, and provides a foundation for larger scale explorations of the use of tDCS as a treatment for reducing tics.
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