ArticleMikrochimica acta2019
Highly selective extraction and voltammetric determination of the opioid drug buprenorphine via a carbon paste electrode impregnated with nano-sized molecularly imprinted polymer.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Molecularly imprinted polymers for illicit drug detection: A review of computational and synthesis methods.Talanta · 2025Review
- Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers.Biomicrofluidics · 2024Review
- Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices.Molecules (Basel, Switzerland) · 2022Review
- Graphene-Based Electrochemical Sensors for Psychoactive Drugs.Nanomaterials (Basel, Switzerland) · 2022Review
- Developments and applications of nanomaterial-based carbon paste electrodes.RSC advances · 2020Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
An electrochemical sensor for the opioid drug buprenorphine (BUP) is described. Molecularly imprinted polymer nanoparticles (nanoMIP) were prepared and used to modify a carbon paste electrode (CPE). The BUP-imprinted polymer was synthesized using precipitation polymerization. The resulting polymer along with multiwalled carbon nanotubes (MWCNT) was used to fabricate the modified CPE which exhibited an anodic peak at about +0.73 V (vs. Ag/AgCl) for BUP. The MIP on the CPE functions as selective recognition element with an imprinting factor of 5.6. The assay consists of two-steps, viz. analyte extraction at the electrode surface and differential pulse voltammetric determination of BUP. The effects of various parameters on the electrochemical signal were optimized, and the selectivity of the modified CPE over cross reactants was studied. At optimum experimental conditions, the response is linear in the 1 nM to 50 μM BUP concentration range, and the detection limit is 0.6 nM (at S/N = 3). This method was applied to the determination of BUP in spiked urine with acceptable relative standard deviations (3.2-4.4%). Graphical abstract Schematic representation of buprenorphine (BUP) recognition and voltammetric determination at the surface of carbon paste electrode modified with imprinted polymer and carbon nanotubes.
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