Evidence map›Paper›PMID 31463392›Full record

ArticleHeliyon2019

Human keratinocyte carcinomas have distinct differences in their tumor-associated macrophages.

Xiaodong Jiang, Mike Wang, Nika Cyrus, Diana A Yanez, Richard K Lacher, Anne Marie Rhebergen, Carolyn Brokowski, Anjela Galan, Samuel Book, Oscar R Colegio

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. The Tumor Microenvironment in SCC: Mechanisms and Therapeutic Opportunities.Frontiers in cell and developmental biology · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaodong JiangDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Mike WangDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Nika CyrusDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Diana A YanezDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Richard K LacherDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Anne Marie RhebergenDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Carolyn BrokowskiDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Anjela GalanDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Samuel BookDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Oscar R ColegioDepartment of Dermatology, Yale University School of Medicine. New Haven, CT, 06520, USA.
Yale University · USRoswell Park Comprehensive Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Cutaneous squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) have different clinical behaviors, despite both being keratinocyte carcinomas mainly caused by ultraviolet radiation. Whether these distinct features are associated with tumor-associated macrophages (TAMs) is largely unknown. The main goal of this study was to conduct a comprehensive analysis of density and polarization states of TAMs in SCCs RESEARCH IN CONTEXT: Few studies have studied tumor-associated macrophages in the context of SCC

Indexed as

Basal cell carcinomaBCCCancer researchCell differentiationImmune responseImmunologyLactic acidMacrophage polarization and densitySCCSquamous cell carcinomaTAMsTumor-associated macrophages

Identifiers

PMID31463392
PMCPMC6706589
OpenAlexW2967917635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.