Evidence map›Paper›PMID 31463366›Full record

ArticleMolecular therapy oncolytics2019

Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis.

Eun-Seo Lee, Sanghoon Moon, Kwaku Dad Abu-Bonsrah, Yun Kyoung Kim, Mi Yeong Hwang, Young Jin Kim, Seokjoong Kim, Nathaniel S Hwang, Hyongbum Henry Kim, Bong-Jo Kim

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In one paragraph

Article in Molecular therapy oncolytics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eun-Seo LeeDepartment of Pharmacology, Yonsei University College of Medicine, Seoul 03372, Republic of Korea.
Sanghoon MoonDivision of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Korea.
Kwaku Dad Abu-BonsrahMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia.
Yun Kyoung KimDivision of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Korea.
Mi Yeong HwangDivision of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Korea.
Young Jin KimDivision of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Korea.
Seokjoong KimToolGen, Seoul 08501, Republic of Korea.
Nathaniel S HwangSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Hyongbum Henry KimDepartment of Pharmacology, Yonsei University College of Medicine, Seoul 03372, Republic of Korea.
Bong-Jo KimDivision of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we found two genomic safe harbor (GSH) candidates from chromosomes 3 and 8, based on large-scale population-based cohort data from 4,694 Koreans by CNV analysis. Furthermore, estimated genotype of these CNVRs was validated by quantitative real-time PCR, and epidemiological data examined no significant genetic association between diseases or traits and two CNVRs. After screening the GSH candidates by

Indexed as

copy number variation regiongenome editingsafe harborTALEN

Identifiers

PMID31463366
PMCPMC6708990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.