ArticleJournal of family medicine and primary care2019
A study to determine the clinical, hematological, cytogenetic, and molecular profile in CML patient in and around Eastern UP, India.
Article in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Safety and efficacy of Vitamin DBMJ open · 2023Trial
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- Clinical spectrum and treatment response in patient of chronic myeloid leukemia in correlation with ABO blood group.Journal of family medicine and primary care · 2022Article
- Article
- False Positivity of rK39 Test in Five Chronic Myeloid Leukemia Cases from Bihar, India: A Possible Challenge to Leishmaniasis Diagnosis.The American journal of tropical medicine and hygiene · 2020Article
- Hematological malignancies in relation with ABO blood group at a teaching hospital, Varanasi, India.Journal of family medicine and primary care · 2020Article
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6 authors.
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Abstract
introductionMyeloproliferative disorders are characterized by proliferation of one or more myeloid lineages cells. In order to assess the burden of these illness for public health planning, it is important to know their frequency.
objectivesA study to determine the clinical, hematological, cytogenetic, and molecular profile in chronic myeloid leukemia (CML) patient in and around Eastern UP, India. MATERIALS AND
methodsNewly diagnosed and follow-up adult and pediatric cases of myeloproliferative disorder were taken into study. Detailed history, physical, and systemic examination was done with informed consent. Investigations like complete blood count including hemoglobin level, platelet count, total and differential leucocyte count, general blood picture, and bone marrow aspiration/biopsy were done. Molecular and cytogenetic studies were also done whenever required.
resultsIn total, 90 patients were enrolled in the study. The median age of presentation of CML was 37 years and the mean age was 38.6 years. M: F ratio of 1.4:1.75 patients (83%) were in CML-chronic phase (CP), 11 patients (12%) in CML-accelerated phase (AP) phase, and 4 patients (5%) were found in CML-blast crisis (BC) phase. The common symptoms of the patients were fullness of the abdomen (66.6%). Among these 69 cases, Philadelphia chromosome was present in 65 (94.2%) cases. Revers transcriptase polymerase chain reaction (RT-PCR) was done in 40 out of 90 cases, breakpoint cluster region (BCR)-Abelson oncogene (ABL) gene came out to be positive in all the 40 cases.
conclusionMost CML patients in eastern UP (India) are relatively young (31-40 years). In addition, males were more commonly affected.
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