Evidence map›Paper›PMID 31463204›Full record

ArticleToxicology reports2019

Lead (Pb) exposure induces dopaminergic neurotoxicity in

Ayodele Jacob Akinyemi, Mahfuzur R Miah, Omamuyovwi M Ijomone, Aristidis Tsatsakis, Félix Alexandre Antunes Soares, Alexey A Tinkov, Anatoly V Skalny, Vivek Venkataramani, Michael Aschner

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease.Central nervous system agents in medicinal chemistry · 2025
    Review
  6. Article
  7. Review
  8. Retinal toxicity of heavy metals and its involvement in retinal pathology.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024
    Review
  9. Article
  10. Article
  11. The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR TInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum.International journal of environmental research and public health · 2021
    Article
  20. The Effect of Lead Exposure on Autism Development.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 6 countries.

Ayodele Jacob AkinyemiDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States.
Mahfuzur R MiahDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States.
Omamuyovwi M IjomoneDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States.
Aristidis TsatsakisLaboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece.
Félix Alexandre Antunes SoaresDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States.
Alexey A TinkovYaroslavl State University, Yaroslavl, Russia.
Anatoly V SkalnyPeoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.
Vivek VenkataramaniDepartment of Hematology and Medical Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States.
Albert Einstein College of Medicine · USSechenov University · RUUniversidade Federal de Santa Maria · BRUniversitätsmedizin Göttingen · DEUniversity of Crete · GRYaroslavl State University · RU

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
NICHD NIH HHS U54 HD083211
6 · The paper itself

Abstract

Lead (Pb) is an environmental neurotoxicant, and has been implicated in several neurological disorders of dopaminergic dysfunction; however, the molecular mechanism of its toxicity has yet to be fully understood. This study investigated the effect of Pb exposure on dopaminergic neurodegeneration and function, as well as expression level of several dopaminergic signaling genes in wild type (N2) and protein kinase C (

Indexed as

dat-1Dopaminergic neuronNeurotoxicantPbPKC

Identifiers

PMID31463204
PMCPMC6709386
OpenAlexW2967124299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.