ArticlePhotoacoustics2019
Optical-resolution photoacoustic microscopy for monitoring vascular normalization during anti-angiogenic therapy.
Article in Photoacoustics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Quantitative longitudinal photoacoustic imaging of vascular oxygenation for therapy response monitoring in Non-Hodgkin lymphoma.Photoacoustics · 2026Article
- Assessing axitinib-induced differential responses in tumor vascularization and oxygenation with combined optoacoustic angiography and diffuse optical spectroscopy.Neoplasia (New York, N.Y.) · 2026Article
- Photoacoustic Imaging for Women's Gynecological Health: Advances and Clinical Prospects.Bioengineering (Basel, Switzerland) · 2026Review
- Characterization of vascular patterns in endometrial cancer via optical resolution photoacoustic microscopy.Journal of biomedical optics · 2026Article
- Multivalent fusion protein targeting VEGFR2 and DR5 receptors: assessing the antiangiogenic and antitumor effects via multimodal microangiography.Journal of translational medicine · 2025Article
- Local laser fluence estimation in optical resolution optoacoustic angiography employing calibrated ultrasound detector.Photoacoustics · 2025Article
- Local oxygen concentration reversal from hyperoxia to hypoxia monitored by optical-resolution photoacoustic microscopy in inflammation-resolution process.Photoacoustics · 2025Article
- Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting.Photoacoustics · 2025Article
- Vascular regional analysis unveils differential responses to anti-angiogenic therapy in pancreatic xenografts through macroscopic photoacoustic imaging.Theranostics · 2025Article
- Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- 3D Multiparametric Photoacoustic Computed Tomography of Primary and Metastatic Tumors in Living Mice.ACS nano · 2024Article
- WSA-MP-Net: Weak-signal-attention and multi-scale perception network for microvascular extraction in optical-resolution photoacoustic microcopy.Photoacoustics · 2024Article
- Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review.Journal of biomedical optics · 2024Review
- Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs.Scientific reports · 2023Article
- Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy.Cancer medicine · 2023Article
- Non-invasive transcranial volumetric ultrasound localization microscopy of the rat brain with continuous, high volume-rate acquisition.Theranostics · 2023Article
- Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications.Biosensors · 2022Review
- Freehand scanning photoacoustic microscopy with simultaneous localization and mapping.Photoacoustics · 2022Article
- Types of spectroscopy and microscopy techniques for cancer diagnosis: a review.Lasers in medical science · 2022Review
- Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monitoring the changes in tumor vascularity is important for anti-angiogenic therapy assessment with therapeutic implications. However, monitoring vascularity is quite challenging due to the lack of appropriate imaging techniques. Here, we describe a non-invasive imaging technique using optical-resolution photoacoustic microscopy (OR-PAM) to track vascular changes in prostate cancer treated with an anti-angiogenic agent, DC101, on a mouse ear xenograft model. Approximately 1-3 days after the initial therapy, OR-PAM imaging detected tumor vascular changes such as reduced vessel tortuosity, decreased vessel diameter and homogenized intratumoral vessel distribution. These observations indicated vessel normalization, which was pathologically validated as increased fractional pericyte coverage, functional perfusion and drug delivery of the vessels. After four DC101 interventions, OR-PAM imaging eventually revealed intratumoral vessel regression. Therefore, OR-PAM imaging of the vasculature offers a promising method to study anti-angiogenic drug mechanisms of action in vivo and holds potential in monitoring and guiding anti-angiogenic therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.