Evidence map›Paper›PMID 31463081›Full record

ArticleIntegrative molecular medicine2019

Unlimited expansion of intestinal stem cells from a wide range of ages.

Marcin Duleba, Rajasekaran Mahalingam, Audrey-Ann Liew, Yutao Qi, Rahul Neupane, Matthew Vincent, Suneal Agarwal, Francisco A Sylvester, Jeffrey S Hyams, Khek Yu Ho and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marcin DulebaDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Rajasekaran MahalingamDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Audrey-Ann LiewDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Yutao QiDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Rahul NeupaneDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Matthew VincentTract Pharmaceuticals, Inc., Marlborough, Massachusetts 01752, USA.
Suneal AgarwalDivision of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA.
Francisco A SylvesterDepartment of Pediatrics, Division of Gastroenterology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Jeffrey S HyamsDivision of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's, Medical Center, Hartford, Connecticut 06106, USA.
Khek Yu HoDepartments of Medicine and Pathology, National University of Singapore, Singapore.
Jason K HouDivision of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA.
Frank McKeonDepartment of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.
Wa XianInstitute of Molecular Medicine, McGovern Medical School of The University of Texas, Health Science Center, Houston, Texas 77030, USA.

Funding

Pathogenic Heterogeneity in Mucosal Stem Cells in Pediatric Crohn's DiseaseR01DK115445 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIAN, WA · 2018 to 2021
$2.6M
New vertebrate model organism cDNA librariesR24RR015088 · NCRR · UNIVERSITY OF CALIFORNIA IRVINE · PI BLUMBERG, BRUCE · 2001 to 2003
$1.1M
Patient-Matched Stem Cells of the Barrett's-Dysplasia-Adenocarcinoma SequenceU24CA228550 · NCI · UNIVERSITY OF HOUSTON · PI MCKEON, FRANK D. · 2017 to 2022
$1.0M
NCI NIH HHS U24 CA228550NCRR NIH HHS R24 RR015088NIDDK NIH HHS R01 DK115445
6 · The paper itself

Abstract

The recent technical advance in cloning and culturing ground-state intestinal stem cells (ISC) provides us an opportunity of accurate assessment of age-related impact on the function of highly proliferative intestinal stem cells. Our ability of indefinitely and robustly expanding single-stem-cell derived pedigrees

Identifiers

PMID31463081
PMCPMC6713279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.