Evidence map›Paper›PMID 31462942›Full record

ArticleThe EPMA journal2019

The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy.

Yu Wang, Yi Shao, Wen-Qing Shi, Lei Jiang, Xiao-Yu Wang, Pei-Wen Zhu, Qing Yuan, Ge Gao, Jin-Lei Lv, Gong-Xian Wang

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In one paragraph

Article in The EPMA journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Yu Wang *1Department of Nephrology, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, Nanchang, 330006 Jiangxi People's Republic of China.
Yi Shao *2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi China.
Wen-Qing Shi2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi China.
Lei Jiang1Department of Nephrology, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, Nanchang, 330006 Jiangxi People's Republic of China.
Xiao-Yu Wang1Department of Nephrology, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, Nanchang, 330006 Jiangxi People's Republic of China.
Pei-Wen Zhu2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi China.
Qing Yuan2Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi China.
Ge Gao3Department of General Surgery, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, Nanchang, 330006 Jiangxi People's Republic of China.
Jin-Lei Lv1Department of Nephrology, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, Nanchang, 330006 Jiangxi People's Republic of China.ORCID 0000-0002-8115-951X
Gong-Xian Wang4Department of Urinary Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe amplitude of low-frequency fluctuation (ALFF) fMRI technique was used to study the changes of spontaneous brain activity in patients with diabetic retinopathy and nephropathy (DRN), and to explore the application of ALFF technique in the potential prediction and the targeted prevention of diabetic microangiopathy.

methodsNineteen patients with diabetic retinopathy and nephropathy and 19 healthy controls (HCs) were matched for age and gender. Spontaneous cerebral activity variations were investigated using the ALFF technique. The average ALFF values of the DRN patients and the HCs were classified utilizing receiver operating characteristic (ROC) curves.

resultsIn contrast to the results in the HCs, the patients with DRN had significantly higher ALFF values in the cerebellum (bilaterally in the posterior and anterior lobes) and the left inferior temporal gyrus, but the ALFF values of the bilateral medial frontal gyrus, right superior temporal gyrus, right middle frontal gyrus, left middle/inferior frontal gyrus, bilateral precuneus, and left inferior parietal lobule were lower. ROC curve analysis of each brain region showed the accuracy of AUC was excellent. However, the mean ALFF values in the different regions did not correlate with clinical performance. The subjects showed abnormal neuronal synchronization in many areas of the brain, which is consistent with cognitive and visual functional deficits.

conclusionAbnormal spontaneous activity was detected in many areas of the brain, which may provide useful information for understanding the pathology of DRN. Abnormal ALFF values of these brain regions may be of predictive value in the development of early DRN and be a targeted intervention indicator for individualized treatment of diabetic microvascular diseases.

Indexed as

ALFFDiabetic microvascular diseasesDiabetic nephropathyDiabetic retinopathyfMRIPredictive preventive personalized medicineResting stateSpontaneous brain activity

Identifiers

PMID31462942
PMCPMC6695464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.